Detecting chronic kidney disease in older people; what are the implications?


Roderick, P.J., Atkins, R.J., Smeeth, L., Nitsch, D.M., Hubbard, R.B., Flectcher, A.E. and Bulpitt, C.J. (2008) Detecting chronic kidney disease in older people; what are the implications? Age and Ageing, 37, (2), 179-186. (doi:10.1093/ageing/afm180).

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Original Publication URL: http://dx.doi.org/10.1093/ageing/afm180

Description/Abstract

BACKGROUND: national policy is focused on early identification, referral and management of chronic kidney disease (CKD) to prevent both progression to endstage renal failure and cardiovascular disease. However, the significance of identifying CKD in older people is unclear.

OBJECTIVE: to determine the frequency of CKD in older people using estimated glomerular filtration rate (eGFR), and its associations with morbidity and functional measures.

DESIGN: observational cross-sectional analysis of baseline data from a large cluster randomised trial of health and social assessment of older people in the community.

SETTING: included 53 general practices in Great Britain.

SUBJECTS: subjects were people aged 75 and over, living in the community participating in the trial arm where systematic blood testing was undertaken.

METHODS: the response rate for participation at baseline assessment of those eligible was 73% (15,536/20,934), of whom 13,109 (86%) participants had a serum creatinine measured, and an eGFR derivable using the Modification of Diet in Renal Disease formula (MDRD) in ml/min/1.73 m(2). Key outcomes were the prevalence of CKD stages and their associations with morbidity and functional status. RESULTS: prevalence of CKD was 56.1% (95% CI 55.3-57.0) for eGFR 45 need to be determined

Item Type: Article
ISSNs: 0002-0729 (print)
Related URLs:
Keywords: design, risk, sex distribution, disease, male, strength, research, multicenter studies as topic, cross-sectional studies, metabolism, prognosis, humans, glomerular filtration rate, public health,chronic, health, serum, risk management, severity of illness index, prevalence,80 and over, arm, activity, survival analysis, diet, hypertension, early diagnosis, national health programs, disease progression, kidney, diabetes, risk assessment, aged, general-practice, outcomes, diagnosis, statistics, community, methods, chronic, organization & administration, mass screening, research support, creatinine, aged, britain, trends, female, analysis, odds ratio, kidney function tests, family practice, epidemiology, participation, kidney failure, age distribution, cardiovascular disease, policy, comorbidity, prevention & control, people, blood, trial,activities of daily living, standards, great britain, morbidity
Subjects: R Medicine
Divisions: University Structure - Pre August 2011 > School of Medicine > Community Clinical Sciences
ePrint ID: 62102
Date Deposited: 02 Sep 2008
Last Modified: 27 Mar 2014 18:44
URI: http://eprints.soton.ac.uk/id/eprint/62102

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