Frequent wheeze at follow up of very preterm infants: which factors are predictive? [In: Fetal and Neonatal Edition]

Thomas, M., Greenough, A., Johnson, A., Limb, E., Marlow, N., Peacock, J.L. and Calvert, S. (2003) Frequent wheeze at follow up of very preterm infants: which factors are predictive? [In: Fetal and Neonatal Edition]. Archives of Disease in Childhood, 88, (4), F329-F332. (doi:10.1136/fn.88.4.F329).


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OBJECTIVE: To determine if chest radiograph appearance at 28 days or 36 weeks postmenstrual age (PMA) can predict recurrent wheeze or cough at follow up in prematurely born infants more effectively than readily available clinical data. DESIGN: Chest radiographs of infants entered into the UKOS trial, who had had a chest radiograph at 28 days and 36 weeks PMA and completed six months of follow up, were assessed for the presence of fibrosis, interstitial shadows, cystic elements, and hyperinflation. At 6 months of corrected age, the occurrence and frequency of wheeze and cough since discharge were determined using a symptom questionnaire. PATIENTS: A total of 185 infants with a median gestational age of 26 (range 23-28) weeks. RESULTS: Thirty seven infants wheezed more than once a week, compared with the rest of the cohort. These infants had significantly higher chest radiograph scores at 28 days (p = 0.020) and 36 weeks PMA (p = 0.005), with significantly higher scores at 28 days for fibrosis (p = 0.017) and at 36 weeks PMA for fibrosis (p = 0.001) and cystic elements (p = 0.0007). They had also been ventilated for longer (p = 0.013). Forty four infants coughed more than once a week; they did not differ significantly from the rest of the cohort. An abnormal chest radiograph score at 36 weeks PMA had the largest area under the receiver operator characteristic curve with regard to prediction of frequent wheeze. CONCLUSION: An abnormal chest radiograph appearance at 36 weeks PMA predicts frequent wheeze at follow up and appears to be a better predictor than readily available clinical data.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1136/fn.88.4.F329
ISSNs: 1359-2998 (print)
Related URLs:
Keywords: cough, pulmonary fibrosis, respiratory sounds, newborn, infant, fibrosis, gestational age, child, diseases, radiography, chest radiograph, follow-up studies, premature, health, infant, lung, research support, diagnosis, humans, predictive value of tests, questionnaire, prediction, artificial, respiration, trial, research, design, cohort, risk factors, age factors, roc curve, london, patients
Subjects: R Medicine > RG Gynecology and obstetrics
R Medicine > RJ Pediatrics
Divisions : University Structure - Pre August 2011 > School of Medicine
ePrint ID: 62157
Accepted Date and Publication Date:
July 2003Published
Date Deposited: 03 Sep 2008
Last Modified: 31 Mar 2016 12:45

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