Genetic variation in the 5-HT2A receptor and altered neocortical [H-3] ketanserin binding in Alzheimer's disease
Holmes, C., McCulley, M., Nicoll, J.A.R., Alder, J.T., Chen, C.P.L.H. and Francis, P.T. (2007) Genetic variation in the 5-HT2A receptor and altered neocortical [H-3] ketanserin binding in Alzheimer's disease. Neuroscience Letters, 420, (1), 58-60. (doi:10.1016/j.neulet.2007.04.009).
Download
Full text not available from this repository.
Description/Abstract
A common intronic single nucleotide polymorphism (T102C) in the 5-HT2A receptor gene is associated with the development of different neuropsychiatric symptoms, including hallucinations and depressive symptoms in Alzheimer's disease (AD). Differential 5-HT2A receptor binding has also been associated with the development of these symptoms in AD. However, the relationship between 5-HT2A (T102C) genotype and 5-HT2A receptor binding in AD and control human brains has not been examined. We examined the association between different 5-HT2A (T102C) genotypes and [H-3] ketanserin binding in the temporal and frontal cortex of 20 AD and 14 control human brains. In homozygotes, but not heterozygotes, there was a significant reduction in B-max values for [H-3] ketanserin binding in both areas of cortex in AD compared with control subjects. This study suggests a mechanism for the generation of different neuropsychiatric symptoms in AD from a single nucleotide polymorphism with reduced receptor binding in T102C 5-HT2A receptor gene homozygotes correlating with susceptibility to depressive symptoms, whereas the relative preservation of receptor binding in heterozygotes with AD correlating with susceptibility to hallucinations.
| Item Type: | Article |
|---|---|
| ISSNs: | 0304-3940 (print) |
| Related URLs: | |
| Keywords: | depression, polymorphism,5-ht2a, ad, neurochemistry, memory, genetics, pathology, receptor-binding, heterosis, human brain, association, brain, alzheimer's disease |
| Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry R Medicine |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Clinical Neurosciences University Structure - Pre August 2011 > School of Medicine University Structure - Pre August 2011 > School of Medicine > Human Genetics |
| Item ID: | 62406 |
| Date Deposited: | 12 Sep 2008 |
| Last Modified: | 01 Jun 2011 05:09 |
| Contributors: | Holmes, C. (Author) McCulley, M. (Author) Nicoll, J.A.R. (Author) Alder, J.T. (Author) Chen, C.P.L.H. (Author) Francis, P.T. (Author) |
| Date: | 8 June 2007 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/62406 |
Actions (login required)
 |
View Item |
