Association between antipsychotic drugs and diabetes


Holt, Richard I. and Peveler, Robert C. (2006) Association between antipsychotic drugs and diabetes. Diabetes, Obesity & Metabolism, 8, (2), 125-135. (doi:10.1111/j.1463-1326.2005.00495.x).

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Description/Abstract

The link between atypical antipsychotic drugs and the development of diabetes has been hotly debated in the literature. In this review, we attempt to classify the various types of data published and presented in a hierarchical basis. Case reports and retrospective pharmacoepidemiological studies suggest that both conventional and atypical antipsychotic medications are associated with an increased risk of glucose abnormalities or diabetes. Prospective data examining the relationship between atypical antipsychotic drugs and diabetes began to emerge in 2003 and are much less conclusive. Estimates of the attributable risk associated with atypical antipsychotic drugs are low. The few studies that have included a placebo group suggest that we cannot necessarily blame antipsychotic medication when diabetes develops in an individual with schizophrenia.

Item Type: Article
ISSNs: 1462-8902 (print)
Related URLs:
Keywords: atypical antipsychotic drugs, diabetes, insulin resistance, schizophrenia
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
R Medicine
R Medicine > RS Pharmacy and materia medica
Divisions: University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
University Structure - Pre August 2011 > School of Medicine > Clinical Neurosciences
University Structure - Pre August 2011 > School of Medicine > Infection, Inflammation and Repair
ePrint ID: 62410
Date Deposited: 12 Sep 2008
Last Modified: 27 Mar 2014 18:44
URI: http://eprints.soton.ac.uk/id/eprint/62410

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