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Syphilitic acute posterior placoid chorioretinitis in nonimmunocompromised patients

Syphilitic acute posterior placoid chorioretinitis in nonimmunocompromised patients
Syphilitic acute posterior placoid chorioretinitis in nonimmunocompromised patients
Purpose: To describe the clinical and angiographic features of three cases of secondary syphilis in immunocompetent patients, which presented as acute posterior placoid chorioretinitis (APPC) to the ophthalmologist.
Methods: Interventional case series. The aetiology of the APPC was confirmed by serology to be secondary syphilis. Optical coherence tomography, electrophysiology, fundus fluorescein, and indocyanine green (ICG) angiography were performed at presentation and after resolution. Appropriate treatment for secondary syphilis was instituted in each patient.
Results: The clinical features, fundus fluorescein and ICG angiography, multifocal electroretinography (mfERG), and optical coherence tomography findings of APPC are described. All three patients had a satisfactory resolution of the APPC with improvement in visual acuity.
Conclusions: APPC in secondary syphilis can occur even in immunocompetent patients. A high index of suspicion is required for early diagnosis of this condition resulting in a good visual outcome with adequate treatment. mfERG and optical coherence tomography are useful in the diagnosis and follow-up of these patients.
chorioretinitis, index, syphilis, optical coherence tomography, treatment, follow-up, acuity, uveitis, eye, diagnosis, clinical-features, multifocal electrophysiology
0950-222X
1114-1119
Joseph, A.
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Rogers, S.
ad6dcbbf-4bb3-4457-ab52-6c0ff81e579f
Browning, A.
e51f55fa-4c73-476c-8acd-33862f645422
Hall, N.
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Barber, C.
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Lotery, A.
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Foley, E.
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Amoaku, W.M.
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Joseph, A.
0e3e6b31-540a-4eba-8b10-e34ec357b4fc
Rogers, S.
ad6dcbbf-4bb3-4457-ab52-6c0ff81e579f
Browning, A.
e51f55fa-4c73-476c-8acd-33862f645422
Hall, N.
e27c10f6-b93d-4e6d-9060-5c8eca345e2c
Barber, C.
b321a79e-1e33-4133-95c3-72366ba76e22
Lotery, A.
5ecc2d2d-d0b4-468f-ad2c-df7156f8e514
Foley, E.
ad887334-6b00-4f29-afe6-7a0b56212566
Amoaku, W.M.
2ed85882-4d83-4223-8f26-459043a098a2

Joseph, A., Rogers, S., Browning, A., Hall, N., Barber, C., Lotery, A., Foley, E. and Amoaku, W.M. (2007) Syphilitic acute posterior placoid chorioretinitis in nonimmunocompromised patients. Eye, 21 (8), 1114-1119. (doi:10.1038/sj.eye.6702504).

Record type: Article

Abstract

Purpose: To describe the clinical and angiographic features of three cases of secondary syphilis in immunocompetent patients, which presented as acute posterior placoid chorioretinitis (APPC) to the ophthalmologist.
Methods: Interventional case series. The aetiology of the APPC was confirmed by serology to be secondary syphilis. Optical coherence tomography, electrophysiology, fundus fluorescein, and indocyanine green (ICG) angiography were performed at presentation and after resolution. Appropriate treatment for secondary syphilis was instituted in each patient.
Results: The clinical features, fundus fluorescein and ICG angiography, multifocal electroretinography (mfERG), and optical coherence tomography findings of APPC are described. All three patients had a satisfactory resolution of the APPC with improvement in visual acuity.
Conclusions: APPC in secondary syphilis can occur even in immunocompetent patients. A high index of suspicion is required for early diagnosis of this condition resulting in a good visual outcome with adequate treatment. mfERG and optical coherence tomography are useful in the diagnosis and follow-up of these patients.

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More information

Published date: 2007
Keywords: chorioretinitis, index, syphilis, optical coherence tomography, treatment, follow-up, acuity, uveitis, eye, diagnosis, clinical-features, multifocal electrophysiology

Identifiers

Local EPrints ID: 62435
URI: http://eprints.soton.ac.uk/id/eprint/62435
ISSN: 0950-222X
PURE UUID: 820af770-c1df-4b79-a848-d024d90924ed
ORCID for A. Lotery: ORCID iD orcid.org/0000-0001-5541-4305

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Date deposited: 08 Sep 2008
Last modified: 16 Mar 2024 03:31

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Contributors

Author: A. Joseph
Author: S. Rogers
Author: A. Browning
Author: N. Hall
Author: C. Barber
Author: A. Lotery ORCID iD
Author: E. Foley
Author: W.M. Amoaku

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