Treatment of obsessive-compulsive disorder
Treatment of obsessive-compulsive disorder
Background: Many randomized controlled trials of the pharmacotherapy and psychotherapy of obsessive-compulsive disorder (OCD) have been undertaken. Several meta-analyses of these trials, and a number of expert consensus guidelines, have been published. This article summarizes these works, and suggests future research directions. Methods: Meta-analyses of OCD were assessed with the QUORUM statement and the Oxman and Guyatt rating scale, and consensus guidelines on the treatment of OCD were assessed with the Appraisal of Guidelines Research and Evaluation (AGREE) instrument. Current principles in the treatment of OCD, and gaps in our knowledge, were reviewed. Results: Selective serotonin reuptake inhibitors (SSRIs) and cognitive-behavioral therapy are currently viewed as the first-line treatments of choice for adult and pediatric OCD. There is also good evidence for the efficacy of atypical antipsychotics in the augmentation of patients refractory to SSRIs. Important questions remain for the field. Conclusions: There have been significant advances in both the pharmacotherapy and psychotherapy of OCD. Nevertheless, there is a paucity of longer-term trials, data on symptom remission and functional improvement, and data on treatment effectiveness in wider clinical practice. It is hoped that improved understanding of the mechanisms underlying OCD will lead to future advances.
methods, serotonin, obsessive compulsive disorder, psychotherapy, effectiveness, patients, evaluation, adult, pharmacotherapy, psychiatry, research, consensus, randomized controlled trials, guidelines, ssri, antipsychotic, treatment, ocd, therapy
28-35
Stein, Dan J.
07cf0cbd-837d-49ac-aceb-1c393a2f3e00
Ipser, Jonathan C.
557d8115-173b-4705-817f-4f4d06775aa9
Baldwin, David S.
1beaa192-0ef1-4914-897a-3a49fc2ed15e
Bandelow, Borwin
2fbbae21-629e-4d76-b5d0-7dff1282d64d
2007
Stein, Dan J.
07cf0cbd-837d-49ac-aceb-1c393a2f3e00
Ipser, Jonathan C.
557d8115-173b-4705-817f-4f4d06775aa9
Baldwin, David S.
1beaa192-0ef1-4914-897a-3a49fc2ed15e
Bandelow, Borwin
2fbbae21-629e-4d76-b5d0-7dff1282d64d
Stein, Dan J., Ipser, Jonathan C., Baldwin, David S. and Bandelow, Borwin
(2007)
Treatment of obsessive-compulsive disorder.
CNS Spectrums, 12 (2, Supplement 3), .
Abstract
Background: Many randomized controlled trials of the pharmacotherapy and psychotherapy of obsessive-compulsive disorder (OCD) have been undertaken. Several meta-analyses of these trials, and a number of expert consensus guidelines, have been published. This article summarizes these works, and suggests future research directions. Methods: Meta-analyses of OCD were assessed with the QUORUM statement and the Oxman and Guyatt rating scale, and consensus guidelines on the treatment of OCD were assessed with the Appraisal of Guidelines Research and Evaluation (AGREE) instrument. Current principles in the treatment of OCD, and gaps in our knowledge, were reviewed. Results: Selective serotonin reuptake inhibitors (SSRIs) and cognitive-behavioral therapy are currently viewed as the first-line treatments of choice for adult and pediatric OCD. There is also good evidence for the efficacy of atypical antipsychotics in the augmentation of patients refractory to SSRIs. Important questions remain for the field. Conclusions: There have been significant advances in both the pharmacotherapy and psychotherapy of OCD. Nevertheless, there is a paucity of longer-term trials, data on symptom remission and functional improvement, and data on treatment effectiveness in wider clinical practice. It is hoped that improved understanding of the mechanisms underlying OCD will lead to future advances.
This record has no associated files available for download.
More information
Published date: 2007
Keywords:
methods, serotonin, obsessive compulsive disorder, psychotherapy, effectiveness, patients, evaluation, adult, pharmacotherapy, psychiatry, research, consensus, randomized controlled trials, guidelines, ssri, antipsychotic, treatment, ocd, therapy
Identifiers
Local EPrints ID: 62611
URI: http://eprints.soton.ac.uk/id/eprint/62611
ISSN: 1092-8529
PURE UUID: eba67dd6-1be2-4402-93a3-ef8931885332
Catalogue record
Date deposited: 20 Apr 2009
Last modified: 12 Dec 2021 02:52
Export record
Contributors
Author:
Dan J. Stein
Author:
Jonathan C. Ipser
Author:
Borwin Bandelow
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
