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The inhibitory receptor NKG2A determines lysis of vaccinia virus-infected autologous targets by NK cells

The inhibitory receptor NKG2A determines lysis of vaccinia virus-infected autologous targets by NK cells
The inhibitory receptor NKG2A determines lysis of vaccinia virus-infected autologous targets by NK cells
Signals transduced by inhibitory receptors that recognize self-MHC class I molecules prevent NK cells from being activated by autologous healthy target cells. In order for NK cells to be activated upon contact with an infected cell, the balance between the activating and inhibitory signals that regulate NK cell function must be altered in favor of activation. By studying liver-derived NK cells, we show that only a subpopulation of NK cells expressing high levels of the inhibitory receptor NKG2A are able to lyse autologous vaccinia-infected targets, and that this is due to selective down-regulation of HLA-E. These data demonstrate that release from an inhibitory receptor:ligand interaction is one mechanism that permits NK cell recognition of a virally infected target, and that the variegated expression of inhibitory receptors in humans generates a repertoire of NK cells with different antiviral potentials.
mechanism, hla class-i, dendritic cells, natural-killer-cells, down-regulation, activation, gene-expression, time, human cytomegalovirus, molecules, hepatitis-c virus, t-cells, molecule qa-1(b), antiviral defense, missing self, cells, cell, expression
0022-1767
1141-1147
Brooks, Colin R.
19014088-df62-4a3d-9461-b96dfcbeadaa
Elliott, Tim
16670fa8-c2f9-477a-91df-7c9e5b453e0e
Parham, Peter
85caaa6b-edd8-4239-b69b-b24043d52f9e
Khakoo, Salim I.
6c16d2f5-ae80-4d9b-9100-6bfb34ad0273
Brooks, Colin R.
19014088-df62-4a3d-9461-b96dfcbeadaa
Elliott, Tim
16670fa8-c2f9-477a-91df-7c9e5b453e0e
Parham, Peter
85caaa6b-edd8-4239-b69b-b24043d52f9e
Khakoo, Salim I.
6c16d2f5-ae80-4d9b-9100-6bfb34ad0273

Brooks, Colin R., Elliott, Tim, Parham, Peter and Khakoo, Salim I. (2006) The inhibitory receptor NKG2A determines lysis of vaccinia virus-infected autologous targets by NK cells. Journal of Immunology, 176 (2), 1141-1147. (doi:10.4049/jimmunol.176.2.1141). (PMID:16434388)

Record type: Article

Abstract

Signals transduced by inhibitory receptors that recognize self-MHC class I molecules prevent NK cells from being activated by autologous healthy target cells. In order for NK cells to be activated upon contact with an infected cell, the balance between the activating and inhibitory signals that regulate NK cell function must be altered in favor of activation. By studying liver-derived NK cells, we show that only a subpopulation of NK cells expressing high levels of the inhibitory receptor NKG2A are able to lyse autologous vaccinia-infected targets, and that this is due to selective down-regulation of HLA-E. These data demonstrate that release from an inhibitory receptor:ligand interaction is one mechanism that permits NK cell recognition of a virally infected target, and that the variegated expression of inhibitory receptors in humans generates a repertoire of NK cells with different antiviral potentials.

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More information

Published date: 15 January 2006
Keywords: mechanism, hla class-i, dendritic cells, natural-killer-cells, down-regulation, activation, gene-expression, time, human cytomegalovirus, molecules, hepatitis-c virus, t-cells, molecule qa-1(b), antiviral defense, missing self, cells, cell, expression

Identifiers

Local EPrints ID: 62697
URI: http://eprints.soton.ac.uk/id/eprint/62697
ISSN: 0022-1767
PURE UUID: 1a559327-1681-42da-8820-c35dcf2a375f
ORCID for Tim Elliott: ORCID iD orcid.org/0000-0003-1097-0222
ORCID for Salim I. Khakoo: ORCID iD orcid.org/0000-0002-4057-9091

Catalogue record

Date deposited: 05 Sep 2008
Last modified: 16 Mar 2024 03:25

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Contributors

Author: Colin R. Brooks
Author: Tim Elliott ORCID iD
Author: Peter Parham
Author: Salim I. Khakoo ORCID iD

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