The inhibitory receptor NKG2A determines lysis of vaccinia virus-infected autologous targets by NK cells
Brooks, Colin R., Elliott, Tim, Parham, Peter and Khakoo, Salim I. (2006) The inhibitory receptor NKG2A determines lysis of vaccinia virus-infected autologous targets by NK cells. Journal of Immunology, 176, (2), 1141-1147. (doi:10.4049/jimmunol.176.2.1141). (PMID:16434388).
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Signals transduced by inhibitory receptors that recognize self-MHC class I molecules prevent NK cells from being activated by autologous healthy target cells. In order for NK cells to be activated upon contact with an infected cell, the balance between the activating and inhibitory signals that regulate NK cell function must be altered in favor of activation. By studying liver-derived NK cells, we show that only a subpopulation of NK cells expressing high levels of the inhibitory receptor NKG2A are able to lyse autologous vaccinia-infected targets, and that this is due to selective down-regulation of HLA-E. These data demonstrate that release from an inhibitory receptor:ligand interaction is one mechanism that permits NK cell recognition of a virally infected target, and that the variegated expression of inhibitory receptors in humans generates a repertoire of NK cells with different antiviral potentials.
|Digital Object Identifier (DOI):||doi:10.4049/jimmunol.176.2.1141|
|Keywords:||mechanism, hla class-i, dendritic cells, natural-killer-cells, down-regulation, activation, gene-expression, time, human cytomegalovirus, molecules, hepatitis-c virus, t-cells, molecule qa-1(b), antiviral defense, missing self, cells, cell, expression|
|Subjects:||Q Science > QR Microbiology > QR180 Immunology
Q Science > QR Microbiology > QR355 Virology
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Cancer Sciences
University Structure - Pre August 2011 > School of Medicine > Infection, Inflammation and Repair
|Date Deposited:||05 Sep 2008|
|Last Modified:||31 Mar 2016 12:46|
Funded by: Wellcome Trust (UNSPECIFIED)
UNSPECIFIED to UNSPECIFIED
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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