Intrinsic versus extrinsic influences in the development of neuronal maps

Elliott, Terry (2007) Intrinsic versus extrinsic influences in the development of neuronal maps. Biological Cybernetics, 96, (1), 129-143. (doi:10.1007/s00422-006-0103-7).


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Accumulating evidence suggests that the plasticity of extrinsic thalamocortical inputs in cortical layer IV may be guided or instructed by earlier plasticity events in the intrinsic, horizontal connections within the extragranular cortical layers. We analyse a rate-based model of the plasticity of a set of extrinsic afferents in the presence of a pre-existing (and fixed) plexus of intrinsic, overall excitatory horizontal connections between a set of target neurons. We determine conditions under which afferent synaptic pattern formation respects this pre-existing lateral structure. We find three broad regimes under which extrinsic afferent plasticity may violate this structure: the initial pattern of extrinsic afferent innervation of the target cells is far from balanced; the gain of the extrinsic afferents greatly exceeds the overall scale of the strength of lateral excitation; the target cell horizontal coupling matrix is sparse. If none of these conditions is satisfied, then extrinsic afferent plasticity respects the pre-existing lateral connectivity, so that afferent synaptic pattern formation conforms to the pattern of lateral excitation.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1007/s00422-006-0103-7
ISSNs: 0340-1200 (print)
Related URLs:
Keywords: model, striate cortex, ocular dominance columns,cat, time, critical period, cell, horizontal connections, primary visual-cortex, development, cells, local circuits, cortical maps, plasticity
Subjects: Q Science > QA Mathematics > QA75 Electronic computers. Computer science
Q Science > QH Natural history > QH301 Biology
Divisions : University Structure - Pre August 2011 > School of Electronics and Computer Science
ePrint ID: 62732
Accepted Date and Publication Date:
7 September 2007Published
Date Deposited: 04 Sep 2008
Last Modified: 31 Mar 2016 12:46

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