Prognosis of children with acute lymphoblastic leukemia (ALL) and intrachromosomal amplification of chromosome 21 (iAMP21)30
Moorman, A.V., Richards, S.M., Robinson, H.M., Strefford, J.C., Gibson, B.E.S., Kinsey, S.E., Eden, T.O.B., Voras, A.J., Mitchell, C.D. and Harrison, C.J. (2007) Prognosis of children with acute lymphoblastic leukemia (ALL) and intrachromosomal amplification of chromosome 21 (iAMP21)30. Blood, 109, (6), 2327-2330. (doi:10.1182/blood-2006-08-040436).
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Description/Abstract
Patients with acute lymphoblastic leukemia (ALL) and an intrachromosomal amplification of chromosome 21 (iAMP21) comprise a novel and distinct biological subgroup. We prospectively screened 1630 (84%) patients treated on the UK MRC ALL97 protocol for iAMP21 and herein present demographic, clinical, and survival data on the 28 (2%) children found to harbor this abnormality. They had a common or pre-BALL immunophenotype, were significantly older (median 9 years vs 5 years), and had a lower white cell count (median 3.9 vs 12.4) compared with children without this abnormality. Notably, patients with iAMP21 had a significantly inferior event-free and overall survival at 5 years compared with other patients: 29% (95% confidence interval [CI], 13%-48%) versus 78% (95% Cl, 76%-80%) and 71% (95% Cl, 51%-84%) versus 87% (95% Cl, 85%-88%), respectively. As a result of this 3-fold increase in relapse risk, newly diagnosed patients with iAMP21 recruited to the current UK MRC ALL2003 trial are being treated on the high-risk arm and are considered for bone marrow transplantation in first remission
| Item Type: | Article |
|---|---|
| ISSNs: | 0006-4971 (print) |
| Related URLs: | |
| Keywords: | abnormalities, children, childhood, risk, time, trial, amplification, patient, aml1, prognosis, protocol, cell, leukemia, acute lymphoblastic leukemia, survival, high-risk |
| Subjects: | R Medicine |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Cancer Sciences |
| Item ID: | 62861 |
| Date Deposited: | 05 Sep 2008 |
| Last Modified: | 02 Mar 2012 12:52 |
| Contributors: | Moorman, A.V. (Author) Richards, S.M. (Author) Robinson, H.M. (Author) Strefford, J.C. (Author) Gibson, B.E.S. (Author) Kinsey, S.E. (Author) Eden, T.O.B. (Author) Voras, A.J. (Author) Mitchell, C.D. (Author) Harrison, C.J. (Author) |
| Date: | 2007 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/62861 |
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