Outcome of treatment in children with hypodiploid acute lymphoblastic leukemia
Outcome of treatment in children with hypodiploid acute lymphoblastic leukemia
One-hundred thirty-nine patients with acute lymphoblastic leukemia (ALL) and hypodiploldly (fewer than 45 chromosomes) were collected from 10 different national ALL study groups and single institutions. Patients were stratified by modal chromosome number into 4 groups: 24 to 29 (N = 46); 33 to 39 (N = 26); 40 to 43 (N = 13); and 44 (N = 54) chromosomes. Nine patients were Philadelphia chromosome (Ph) positive (4 cases: 44 chromosomes; 5 cases: 40-43 chromosomes) and were not considered further. Event-free survival (EFS) and overall survival (OS) of the remaining 130 patients were 38.5% 4.4% and 49.80/6 4.2% at 8 years, respectively. There were no significant differences in outcome between patients with 24 to 29, 33 to 39, or 40 to 43 chromosomes. Compared with patients with fewer than 44 chromosomes, patients with 44 chromosomes had a significantly better EFS (P=.01; 8-year estimate, 52.2% vs 30.1 9/6) and OS (P =.017; 691% vs 37.50/6). For patients with 44 chromosomes, monosomy 7, the presence of a dicentric chromosome, or both predicted worse EFS but similar OS. Doubling of the hypodiplold clone occurred in 32 patients (24-29 chromosomes [n = 25] and 33 39 chromosomes [n = 7]) and had no prognostic implication. Children and adolescents with ALL and hypodiploidy with fewer than 44 chromosomes have a poor outcome despite contemporary therapy.
leukemia, chromosomes, time, patient, children, survival, poor-prognosis
1112-1115
Nachman, J.B.
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Heerema, N.A.
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Sather, H.
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Camitta, B.
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Forestier, E.
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Harrison, C.J.
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Dastugue, N.
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Schrappe, M.
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Pui, C.H.
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Basso, G.
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Silverman, L.B.
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Janka-Schaub, G.E.
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2007
Nachman, J.B.
ebdab255-d804-49f1-911c-7b3be1ecbdde
Heerema, N.A.
6fb2d3a1-988b-46c7-b0e0-6930da02c27e
Sather, H.
d0a02dd0-9814-4a84-b50b-c62417b369b5
Camitta, B.
708070c8-fb6a-4743-b2c4-063605a2b088
Forestier, E.
510b4be0-729c-4ee4-8885-541a2c745b00
Harrison, C.J.
9c9f6b47-8bfc-49dd-b156-74539b170291
Dastugue, N.
2e90b4f4-d6e1-4c14-aac8-5930ab4a930e
Schrappe, M.
5d8412b4-1b04-4b91-8244-d2cd9376acd9
Pui, C.H.
328aaa19-53dd-4e8e-858b-ab5160be1d7d
Basso, G.
4f8d2943-2e87-4e0f-ab63-0e85ad33b85b
Silverman, L.B.
0e6635bc-ddd5-44eb-8ff9-1d3a76048096
Janka-Schaub, G.E.
5b8fea27-2fc5-4a3e-b0fb-b991293caf8a
Nachman, J.B., Heerema, N.A., Sather, H., Camitta, B., Forestier, E., Harrison, C.J., Dastugue, N., Schrappe, M., Pui, C.H., Basso, G., Silverman, L.B. and Janka-Schaub, G.E.
(2007)
Outcome of treatment in children with hypodiploid acute lymphoblastic leukemia.
Blood, 110 (4), .
(doi:10.1182/blood-2006-07-038299).
Abstract
One-hundred thirty-nine patients with acute lymphoblastic leukemia (ALL) and hypodiploldly (fewer than 45 chromosomes) were collected from 10 different national ALL study groups and single institutions. Patients were stratified by modal chromosome number into 4 groups: 24 to 29 (N = 46); 33 to 39 (N = 26); 40 to 43 (N = 13); and 44 (N = 54) chromosomes. Nine patients were Philadelphia chromosome (Ph) positive (4 cases: 44 chromosomes; 5 cases: 40-43 chromosomes) and were not considered further. Event-free survival (EFS) and overall survival (OS) of the remaining 130 patients were 38.5% 4.4% and 49.80/6 4.2% at 8 years, respectively. There were no significant differences in outcome between patients with 24 to 29, 33 to 39, or 40 to 43 chromosomes. Compared with patients with fewer than 44 chromosomes, patients with 44 chromosomes had a significantly better EFS (P=.01; 8-year estimate, 52.2% vs 30.1 9/6) and OS (P =.017; 691% vs 37.50/6). For patients with 44 chromosomes, monosomy 7, the presence of a dicentric chromosome, or both predicted worse EFS but similar OS. Doubling of the hypodiplold clone occurred in 32 patients (24-29 chromosomes [n = 25] and 33 39 chromosomes [n = 7]) and had no prognostic implication. Children and adolescents with ALL and hypodiploidy with fewer than 44 chromosomes have a poor outcome despite contemporary therapy.
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Published date: 2007
Keywords:
leukemia, chromosomes, time, patient, children, survival, poor-prognosis
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Local EPrints ID: 62864
URI: http://eprints.soton.ac.uk/id/eprint/62864
ISSN: 0006-4971
PURE UUID: c3ab545b-75af-46d7-9781-3808bbeab8a9
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Date deposited: 11 Sep 2008
Last modified: 15 Mar 2024 11:33
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Author:
J.B. Nachman
Author:
N.A. Heerema
Author:
H. Sather
Author:
B. Camitta
Author:
E. Forestier
Author:
C.J. Harrison
Author:
N. Dastugue
Author:
M. Schrappe
Author:
C.H. Pui
Author:
G. Basso
Author:
L.B. Silverman
Author:
G.E. Janka-Schaub
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