Molecular machinations of the MHC-I peptide loading complex
Purcell, A.W. and Elliott, T. (2008) Molecular machinations of the MHC-I peptide loading complex. Current Opinion in Immunology, 20, (1), 75-81.
Full text not available from this repository.
The acquisition of an optimal peptide ligand by MHC class I molecules is crucial for the generation of immunity to viruses and tumors. This process is orchestrated by a molecular machine known as the peptide loading complex (PLC) that consists of specialized and general ER-resident molecules. These proteins collaborate to ensure the loading of an optimal peptide ligand into the antigen binding cleft of class I molecules. The surprising diversity of peptides bound to MHC class I molecules and recapitulation of class I assembly in vitro have provided new insights into the molecular machinations of peptide loading. Coupled with the extraordinary polymorphism of class I molecules and their differential dependence on various components of the PLC for cell surface expression, a picture of peptide loading at the molecular level has recently emerged and will be discussed herein
|Keywords:||antigen, cell, endoplasmic-reticulum, expression, t-cell recognition, tapasin, time, protein, surface expression, erp57, in-vitro, tap, alpha-2 domain, antigen presentation, binding, immunity,absence, tumors|
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Cancer Sciences
|Date Deposited:||10 Sep 2008|
|Last Modified:||01 Jun 2011 05:07|
|Contributors:||Purcell, A.W. (Author)
Elliott, T. (Author)
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
Actions (login required)