Molecular machinations of the MHC-I peptide loading complex
Purcell, A.W. and Elliott, T. (2008) Molecular machinations of the MHC-I peptide loading complex. Current Opinion in Immunology, 20, (1), 75-81.
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Description/Abstract
The acquisition of an optimal peptide ligand by MHC class I molecules is crucial for the generation of immunity to viruses and tumors. This process is orchestrated by a molecular machine known as the peptide loading complex (PLC) that consists of specialized and general ER-resident molecules. These proteins collaborate to ensure the loading of an optimal peptide ligand into the antigen binding cleft of class I molecules. The surprising diversity of peptides bound to MHC class I molecules and recapitulation of class I assembly in vitro have provided new insights into the molecular machinations of peptide loading. Coupled with the extraordinary polymorphism of class I molecules and their differential dependence on various components of the PLC for cell surface expression, a picture of peptide loading at the molecular level has recently emerged and will be discussed herein
| Item Type: | Article |
|---|---|
| ISSNs: | 0952-7915 (print) |
| Related URLs: | |
| Keywords: | antigen, cell, endoplasmic-reticulum, expression, t-cell recognition, tapasin, time, protein, surface expression, erp57, in-vitro, tap, alpha-2 domain, antigen presentation, binding, immunity,absence, tumors |
| Subjects: | R Medicine |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Cancer Sciences |
| Item ID: | 62885 |
| Date Deposited: | 10 Sep 2008 |
| Last Modified: | 01 Jun 2011 05:07 |
| Contributors: | Purcell, A.W. (Author) Elliott, T. (Author) |
| Date: | 2008 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/62885 |
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