The effect of mannitol on renal function after cardiopulmonary bypass in patients with established renal dysfunction
The effect of mannitol on renal function after cardiopulmonary bypass in patients with established renal dysfunction
The usefulness of mannitol in the priming fluid for cardiopulmonary bypass is uncertain in patients with normal renal function, and has not been studied in patients with established renal dysfunction. We studied 50 patients with serum creatinine between 130 and 250 mu mol.l(-1) having cardiac surgery. Patients were randomised to receive mannitol 0.5 g.kg(-1), or an equivalent volume of Hartmann's solution, in the bypass prime. There were no differences between the groups in plasma creatinine or change in creatinine from baseline, urine output, or fluid balance over the first three postoperative days. We conclude that mannitol has no effect on routine measures of renal function during cardiac surgery in patients with established renal dysfunction
time, failure, management, surgery, serum, dopamine, mortality, risk-factors, patient, prevention, cardiac-surgery
701-704
Smith, M.N.A.
152c8d32-d273-420c-815d-dffd8510293b
Best, D.
ae2bb183-3f74-4933-8c87-123bf62f0e06
Sheppard, S.V.
e1cda445-ccea-4633-a11a-95a28ca31313
Smith, D.C.
217b19f1-7588-4d54-a062-8394eea6dea1
2008
Smith, M.N.A.
152c8d32-d273-420c-815d-dffd8510293b
Best, D.
ae2bb183-3f74-4933-8c87-123bf62f0e06
Sheppard, S.V.
e1cda445-ccea-4633-a11a-95a28ca31313
Smith, D.C.
217b19f1-7588-4d54-a062-8394eea6dea1
Smith, M.N.A., Best, D., Sheppard, S.V. and Smith, D.C.
(2008)
The effect of mannitol on renal function after cardiopulmonary bypass in patients with established renal dysfunction.
Anaesthesia, 63 (7), .
(doi:10.1111/j.1365-2044.2007.05408.x).
Abstract
The usefulness of mannitol in the priming fluid for cardiopulmonary bypass is uncertain in patients with normal renal function, and has not been studied in patients with established renal dysfunction. We studied 50 patients with serum creatinine between 130 and 250 mu mol.l(-1) having cardiac surgery. Patients were randomised to receive mannitol 0.5 g.kg(-1), or an equivalent volume of Hartmann's solution, in the bypass prime. There were no differences between the groups in plasma creatinine or change in creatinine from baseline, urine output, or fluid balance over the first three postoperative days. We conclude that mannitol has no effect on routine measures of renal function during cardiac surgery in patients with established renal dysfunction
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Published date: 2008
Keywords:
time, failure, management, surgery, serum, dopamine, mortality, risk-factors, patient, prevention, cardiac-surgery
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Local EPrints ID: 62930
URI: http://eprints.soton.ac.uk/id/eprint/62930
ISSN: 0003-2409
PURE UUID: 96c552b8-b272-45d1-b188-7b84e58d3273
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Date deposited: 02 Sep 2008
Last modified: 15 Mar 2024 11:33
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Author:
M.N.A. Smith
Author:
D. Best
Author:
S.V. Sheppard
Author:
D.C. Smith
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