Intraoperative optical measurement of function in the human brain
Hoy, P.R., Rutt, H.N., Gray, W.P. and Bulters, D.O. (2009) Intraoperative optical measurement of function in the human brain. In, Proceedings of Photonics West: Biomedical Optics (BiOS) 2009. SPIE 2009 BiOS Biomedical Optics Symposium: Optical Techniques in Neurosurgery, Brain Imaging and Neurobiology Conference Bellingham, USA, Society of Photo-Optical Instrumentation Engineers. (Proceedings of SPIE). (In Press).
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Intraoperative determination of function is important to surgeons to maximize the outcome of surgery, for example the extent of tumor resection, and minimize post-surgical deficit. This paper will outline the continued work developing a camera system sensitive to tissue blood oxygen level. Tissue blood oxygen level although not a direct measure of activation is exploited by functional MRI (fMRI) to infer eloquence and has a high correlation with other techniques. Current intraoperative techniques such as electro-cortical stimulation use an alternating electrical current to inhibit brain function in the area it is applied. The patient is then required to perform a task or report sensation; this takes time and provides a rather limited resolution (typically about 5mm). Preoperative techniques such as fMRI and PET suffer from poor spatial resolution (typically 4mm) and more importantly registration issues as brain tissue can move by as much as 15mm during surgery. The camera system images the entire surgical field at a high resolution and may provide the surgeon with real-time information. Initially data was collected using a free standing camera optimized for high signal to noise. These results showed a high correlation with electro-cortical stimulation. The latest development of this camera has seen it attached to a Zeiss surgical microscope to provide an improved perspective on the surgical field. Results from this system are expected shortly and are expected to establish a strong correlation with current techniques and to provide real-time information.
|Item Type:||Book Section|
|Subjects:||R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
R Medicine > RD Surgery
T Technology > TK Electrical engineering. Electronics Nuclear engineering
|Divisions:||University Structure - Pre August 2011 > Optoelectronics Research Centre
University Structure - Pre August 2011 > School of Medicine
|Date Deposited:||31 Mar 2009|
|Last Modified:||08 Jan 2013 11:02|
|Publisher:||Society of Photo-Optical Instrumentation Engineers|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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