de Silva, Prasanna, Carare, Roxana O. and Weller, Roy O.
Failure of elimination of amyloid-beta from the brain in Alzheimer's disease.
Progress in Neurology and Psychiatry, 12, (4), . (doi:10.1002/pnp.72).
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Accumulation of amyloid-beta (A-beta) in the brain is a major cause of dementia in Alzheimer's disease.I n this article, Dr de Silva, Dr Carare and ProfessorWeller review the mechanisms for the elimination of A-beta from the brain, the reasons why these mechanisms fail in Alzheimer's disease, and how understanding this failure may lead to new approaches to the treatment of Alzheimer's disease.
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