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Failure of elimination of amyloid-beta from the brain in Alzheimer's disease

Failure of elimination of amyloid-beta from the brain in Alzheimer's disease
Failure of elimination of amyloid-beta from the brain in Alzheimer's disease
Accumulation of amyloid-beta (A-beta) in the brain is a major cause of dementia in Alzheimer's disease.I n this article, Dr de Silva, Dr Carare and ProfessorWeller review the mechanisms for the elimination of A-beta from the brain, the reasons why these mechanisms fail in Alzheimer's disease, and how understanding this failure may lead to new approaches to the treatment of Alzheimer's disease.
1367-7543
6-10
de Silva, Prasanna
372f3fa7-d464-46f8-a36f-0dd86e64a671
Carare, Roxana O.
0478c197-b0c1-4206-acae-54e88c8f21fa
Weller, Roy O.
4a501831-e38a-4d39-a125-d7141d6c667b
de Silva, Prasanna
372f3fa7-d464-46f8-a36f-0dd86e64a671
Carare, Roxana O.
0478c197-b0c1-4206-acae-54e88c8f21fa
Weller, Roy O.
4a501831-e38a-4d39-a125-d7141d6c667b

de Silva, Prasanna, Carare, Roxana O. and Weller, Roy O. (2008) Failure of elimination of amyloid-beta from the brain in Alzheimer's disease. Progress in Neurology and Psychiatry, 12 (4), 6-10. (doi:10.1002/pnp.72).

Record type: Article

Abstract

Accumulation of amyloid-beta (A-beta) in the brain is a major cause of dementia in Alzheimer's disease.I n this article, Dr de Silva, Dr Carare and ProfessorWeller review the mechanisms for the elimination of A-beta from the brain, the reasons why these mechanisms fail in Alzheimer's disease, and how understanding this failure may lead to new approaches to the treatment of Alzheimer's disease.

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More information

Published date: May 2008

Identifiers

Local EPrints ID: 66621
URI: http://eprints.soton.ac.uk/id/eprint/66621
DOI: doi:10.1002/pnp.72
ISSN: 1367-7543
PURE UUID: 8b665436-bd1b-478c-8f24-50c6580ceb1a
ORCID for Roxana O. Carare: ORCID iD orcid.org/0000-0001-6458-3776

Catalogue record

Date deposited: 02 Jul 2009
Last modified: 14 Mar 2024 02:42

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Contributors

Author: Prasanna de Silva
Author: Roxana O. Carare ORCID iD
Author: Roy O. Weller

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