Muscle microvascular dysfunction in central obesity is related to muscle insulin insensitivity but Is not reversed by high-dose statin treatment
Clough, Geraldine F., Turzyniecka, Magdalena, Walter, Lara, Krentz, Andrew J., Wild, Sarah H., Chipperfield, Andrew J., Gamble, John and Byrne, Christopher D. (2009) Muscle microvascular dysfunction in central obesity is related to muscle insulin insensitivity but Is not reversed by high-dose statin treatment. Diabetes, 58, (5), 1185-1191. (doi:10.2337/db08-1688).
Objective: to test the hypotheses that decreased insulin-mediated glucose disposal in muscle is associated with a reduced muscle microvascular exchange capacity (Kf) and that 6 months of high-dose statin therapy would improve microvascular function in people with central obesity.
Research design and methods: we assessed skeletal muscle microvascular function, visceral fat mass, physical activity levels, fitness, and insulin sensitivity in skeletal muscle in 22 female and 17 male volunteers with central obesity whose age (mean ± SD) was 51 ± 9 years. We tested the effect of atorvastatin (40 mg daily) on muscle microvascular function in a randomized, double-blind, placebo-controlled trial lasting 6 months.
Results: Kf was negatively associated with a measure of glycemia (A1C; r = −0.44, P = 0.006) and positively associated with insulin sensitivity (the ratio of insulin-stimulated glucose effectiveness, or M value, to the mean insulin concentration, or I value; r = 0.39, P = 0.02). In regression modeling, A1C, visceral fat mass, and M:I explained 38% of the variance in Kf (in a linear regression model with Kf as the outcome [R2 = 0.38, P = 0.005]). M:I was associated with Kf independently of visceral fat mass (B coefficient 3.13 [95% CI 0.22–6.02], P = 0.036). Although 6 months' treatment with atorvastatin decreased LDL cholesterol by 51% (P < 0.001) and plasma high-sensitivity C-reactive protein by 75% (P = 0.02), microvascular function was unchanged.
Conclusions: decreased insulin-mediated glucose uptake in skeletal muscle is associated with impaired muscle microvascular exchange capacity (Kf), independently of visceral fat mass. Muscle microvascular function is not improved by 6 months of high-dose statin treatment, despite marked statin-mediated improvements in lipid metabolism and decreased inflammation.
|Keywords:||obesity, diabetes, statins, insulin sensitivity|
|Subjects:||R Medicine > RB Pathology
R Medicine > RS Pharmacy and materia medica
R Medicine > RM Therapeutics. Pharmacology
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
University Structure - Pre August 2011 > School of Engineering Sciences > Computational Engineering and Design
|Date Deposited:||25 Aug 2009|
|Last Modified:||08 Jun 2012 12:29|
|Contributors:||Clough, Geraldine F. (Author)
Turzyniecka, Magdalena (Author)
Walter, Lara (Author)
Krentz, Andrew J. (Author)
Wild, Sarah H. (Author)
Chipperfield, Andrew J. (Author)
Gamble, John (Author)
Byrne, Christopher D. (Author)
|Date:||10 February 2009|
|Contact Email Address:||C.D.Byrne@soton.ac.uk|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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