Papillary and verrucous lesions of the oral mucosa
Papillary and verrucous lesions of the oral mucosa
A variety of verrucous and papillary lesions affect the oral mucosa. Those which are benign and reactive, e.g. squamous papilloma, verruciform xanthoma, usually present little diagnostic difficulty. However, dysplastic and malignant verrucous and papillary lesions are a much greater diagnostic challenge not helped by confusing terminology. For example, papillary hyperplasia is a reactive inflammatory condition, whereas verrucous hyperplasia is a potentially malignant dysplasia, and probably part of the spectrum of verrucous carcinoma. Papillary carcinomas, at least in the oral context, are essentially verrucous hyperplasias. “Oral florid papillomatosis” is an obsolete term synonymous with verrucous carcinoma. A “classical” verrucous carcinoma, with an exo-/endophytic growth pattern, “pushing” invasive front and intact basement membrane, is easily identified, but many exophytic verrucous hyperplasias also show endophytic growth. These can also reasonably be diagnosed as verrucous carcinoma. If the lesion shows more than focal, early invasive disruption of the basement membrane, it should be diagnosed as a conventional squamous cell carcinoma.
Thomas, G.J.
2ff54aa9-a766-416b-91ee-cf1c5be74106
Barrett, A.W.
1a3b99ef-990e-4dae-8fe0-ab903085699e
Thomas, G.J.
2ff54aa9-a766-416b-91ee-cf1c5be74106
Barrett, A.W.
1a3b99ef-990e-4dae-8fe0-ab903085699e
Thomas, G.J. and Barrett, A.W.
(2009)
Papillary and verrucous lesions of the oral mucosa.
Histopathology.
(In Press)
Abstract
A variety of verrucous and papillary lesions affect the oral mucosa. Those which are benign and reactive, e.g. squamous papilloma, verruciform xanthoma, usually present little diagnostic difficulty. However, dysplastic and malignant verrucous and papillary lesions are a much greater diagnostic challenge not helped by confusing terminology. For example, papillary hyperplasia is a reactive inflammatory condition, whereas verrucous hyperplasia is a potentially malignant dysplasia, and probably part of the spectrum of verrucous carcinoma. Papillary carcinomas, at least in the oral context, are essentially verrucous hyperplasias. “Oral florid papillomatosis” is an obsolete term synonymous with verrucous carcinoma. A “classical” verrucous carcinoma, with an exo-/endophytic growth pattern, “pushing” invasive front and intact basement membrane, is easily identified, but many exophytic verrucous hyperplasias also show endophytic growth. These can also reasonably be diagnosed as verrucous carcinoma. If the lesion shows more than focal, early invasive disruption of the basement membrane, it should be diagnosed as a conventional squamous cell carcinoma.
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Submitted date: 2009
Accepted/In Press date: 2009
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Local EPrints ID: 66683
URI: http://eprints.soton.ac.uk/id/eprint/66683
ISSN: 1365-2559
PURE UUID: b4288528-1f03-4aad-89be-13d7b648a21c
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Date deposited: 13 Jul 2009
Last modified: 22 Jul 2022 17:01
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Author:
A.W. Barrett
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