αvβ6 integrin promotes invasion of squamous carcinoma cells through up-regulation of matrix metalloproteinase-9


Thomas, Gareth J., Lewis, Mark P., Hart, Ian R., Marshall, John F. and Speight, Paul M. (2001) αvβ6 integrin promotes invasion of squamous carcinoma cells through up-regulation of matrix metalloproteinase-9. International Journal of Cancer, 92, (5), 641-650. (doi:10.1002/1097-0215(20010601)92:5<641::AID-IJC1243>3.0.CO;2-P).

Download

[img] PDF - Version of Record
Restricted to System admin

Download (729Kb) | Request a copy

Description/Abstract

The integrin αVβ6 is a fibronectin receptor, which is not detectable on normal epithelium but is neo-expressed in oral epithelial dysplasia and oral squamous-cell carcinoma (SCC), suggesting a role in promoting malignant behaviour and tumour progression. We used transfection and retroviral infection to create a panel of SCC cell lines expressing various levels of αVβ6 to examine this possibility. We found that increased expression of αVβ6 in malignant keratinocytes up-regulates MMP-9 and MMP-2 expression and promotes invasion in an MMP-9-dependent manner. Our results suggest a possible mechanism for the involvement of αVβ6 in squamous carcinoma in vivo.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1002/1097-0215(20010601)92:5<641::AID-IJC1243>3.0.CO;2-P
ISSNs: 0020-7136 (print)
Related URLs:
Subjects: R Medicine > RB Pathology
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Q Science > QH Natural history > QH301 Biology
Divisions: University Structure - Pre August 2011 > School of Medicine > Cancer Sciences
ePrint ID: 66693
Date Deposited: 10 Jul 2009
Last Modified: 06 Aug 2015 02:53
URI: http://eprints.soton.ac.uk/id/eprint/66693

Actions (login required)

View Item View Item

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics