αvβ6 integrin promotes invasion of squamous carcinoma cells through up-regulation of matrix metalloproteinase-9
Thomas, Gareth J., Lewis, Mark P., Hart, Ian R., Marshall, John F. and Speight, Paul M. (2001) αvβ6 integrin promotes invasion of squamous carcinoma cells through up-regulation of matrix metalloproteinase-9. International Journal of Cancer, 92, (5), 641-650. (doi:10.1002/1097-0215(20010601)92:5<641::AID-IJC1243>3.0.CO;2-P).
The integrin αVβ6 is a fibronectin receptor, which is not detectable on normal epithelium but is neo-expressed in oral epithelial dysplasia and oral squamous-cell carcinoma (SCC), suggesting a role in promoting malignant behaviour and tumour progression. We used transfection and retroviral infection to create a panel of SCC cell lines expressing various levels of αVβ6 to examine this possibility. We found that increased expression of αVβ6 in malignant keratinocytes up-regulates MMP-9 and MMP-2 expression and promotes invasion in an MMP-9-dependent manner. Our results suggest a possible mechanism for the involvement of αVβ6 in squamous carcinoma in vivo.
|Subjects:||R Medicine > RB Pathology
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Q Science > QH Natural history > QH301 Biology
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Cancer Sciences
|Date Deposited:||10 Jul 2009|
|Last Modified:||08 Jun 2012 12:29|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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