???6 Integrin upregulates matrix metalloproteinase 9 and promotes migration of normal oral keratinocytes

Thomas, Gareth J., Poomsawat, S., Lewis, Mark P., Hart, Ian R., Speight, Paul M. and Marshall, John F. (2001) ???6 Integrin upregulates matrix metalloproteinase 9 and promotes migration of normal oral keratinocytes. Journal of Investigative Dermatology, 16, (6), 898-904. (doi:10.1046/j.1523-1747.2001.01352.x).


[img] PDF - Version of Record
Restricted to System admin

Download (216Kb) | Request a copy


The integrin ?v?6 is a fibronectin receptor that is undetectable on normal keratinocytes in situ, but is increased significantly in wound healing and in culture-established keratinocytes, suggesting that it may promote changes associated with cell motility. Using normal human oral keratinocytes we have shown that cultured cells express relatively high levels of ?v?6 and this integrin has a functional role in both cell adhesion and migration towards fibronectin. We provide experimental evidence that the increased expression of ?v?6 by normal human oral keratinocytes results in coordinate changes, which promote a more migratory phenotype. Thus increased expression of ?v?6 results in a fibronectin-dependent increase in pro-matrix metalloproteinase 9, matrix metalloproteinase 9 activity increases normal human oral keratinocyte migration, and this may be further dependent on plasmin activation. The results suggest a key role for ?v?6 in these processes and indicate a coordinated link between ?v?6 expression and upregulation of matrix metalloproteinase 9. It appears that ?v?6 may function in normal human oral keratinocyte migration through matrix-metalloproteinase-9-dependent and -independent mechanisms.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1046/j.1523-1747.2001.01352.x
ISSNs: 0022202 (print)
Related URLs:
Keywords: integrins, keratinocytes, metalloproteinases, migration
Subjects: R Medicine > RB Pathology
R Medicine > RL Dermatology
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions : University Structure - Pre August 2011 > School of Medicine > Cancer Sciences
ePrint ID: 66695
Accepted Date and Publication Date:
June 2001Published
Date Deposited: 10 Jul 2009
Last Modified: 31 Mar 2016 12:52
URI: http://eprints.soton.ac.uk/id/eprint/66695

Actions (login required)

View Item View Item

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics