Research in anxiety disorders: from the bench to the bedside


Garner, Matthew, Möhler, Hanns, Stein, Dan J., Mueggler, Thomas and Baldwin, David S. (2009) Research in anxiety disorders: from the bench to the bedside. European Neuropsychopharmacology, 19, (6), 381-390. (doi:10.1016/j.euroneuro.2009.01.011).

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Description/Abstract

The development of ethologically based behavioural animal models has clarified the
anxiolytic properties of a range of neurotransmitter and neuropeptide receptor agonists and
antagonists, with several models predicting efficacy in human clinical samples.
Neuro-cognitive models of human anxiety and findings from fMRI suggest dysfunction in amygdalaprefrontal
circuitry underlies biases in emotion activation and regulation. Cognitive and neural
mechanisms involved in emotion processing can be manipulated pharmacologically, and research
continues to identify genetic polymorphisms and interactions with environmental risk factors that
co-vary with anxiety-related behaviour and neuro-cognitive endophenotypes.
This paper describes findings from a range of research strategies in anxiety, discussed at the
recent ECNP Targeted Expert Meeting on anxiety disorders and anxiolytic drugs. The efficacy of
existing pharmacological treatments for anxiety disorders is discussed, with particular reference to
drugs modulating serotonergic, noradrenergic and gabaergic mechanisms, and novel targets
including glutamate, CCK, NPY, adenosine and AVP. Clinical and neurobiological predictors of
active treatment and placebo response are considered.

Item Type: Article
ISSNs: 0924-977X (print)
Related URLs:
Keywords: anxiety, treatment, imaging, cognition
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
R Medicine > RM Therapeutics. Pharmacology
B Philosophy. Psychology. Religion > BF Psychology
Divisions: University Structure - Pre August 2011 > School of Medicine > Clinical Neurosciences
University Structure - Pre August 2011 > School of Psychology > Division of Clinical Neuroscience
ePrint ID: 66749
Date Deposited: 16 Jul 2009
Last Modified: 27 Mar 2014 18:47
Contact Email Address: m.j.garner@soton.ac.uk
URI: http://eprints.soton.ac.uk/id/eprint/66749

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