Immune-to-brain signalling: the role of cerebral CD163-positive macrophages
Galea, Ian, Felton, Leigh M., Waters, Sara, van Rooijen, Nico, Perry, V. Hugh and Newman, Tracey A. (2008) Immune-to-brain signalling: the role of cerebral CD163-positive macrophages. Neuroscience Letters, 448, (1), 41-46. (doi:10.1016/j.neulet.2008.09.081). (PMID:18852025).
Systemic inflammation induces cytokine synthesis within the central nervous system. This results in sickness behaviour and may exacerbate ongoing neuroinflammatory disease. The precise mechanisms underlying the relay of signal from the periphery to the central nervous system are not entirely understood. CD163-positive macrophages occupy a unique position at the blood-brain barrier and upregulate prostaglandin-synthesizing enzymes in response to systemic inflammation. This finding suggests that they might play a role in signalling inflammation to the central nervous system. However, here we demonstrate that de novo brain cytokine transcription during systemic endotoxaemia may be prostaglandin-independent. We therefore set out to interrogate more directly the role of CD163-positive macrophages in immune-to-brain signalling. Intracerebroventricular injections of clodronate liposomes were used to selectively deplete CD163-positive macrophages. We show that de novo brain cytokine synthesis during systemic endotoxaemia persists in the absence of CD163-positive macrophages. Cerebral endothelial cells outnumber CD163-positive macrophages and are arguably better situated to signal circulating inflammatory stimuli to the brain.
|Subjects:||Q Science > QP Physiology
Q Science > QR Microbiology > QR180 Immunology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
|Divisions:||University Structure - Pre August 2011 > School of Biological Sciences
|Date Deposited:||10 Sep 2009|
|Last Modified:||08 Jun 2012 12:30|
|Contact Email Address:||I.Galea@soton.ac.uk|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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