Developmental origins of osteoporotic fracture
Developmental origins of osteoporotic fracture
Osteoporosis is a skeletal disorder characterised by low bone mass and micro-architectural deterioration of bone tissue with a consequent increase in bone fragility and susceptibility to fracture.1 It is a widespread condition, often unrecognised in clinical practice, which may have devastating health consequences through its association with fragility fractures. The term ‘osteoporosis’ was first used in the nineteenth century as a histologic description for aged bone tissue, but its clinical consequences were not appreciated until Sir Astley Cooper recognised that hip fractures might result from an age-related reduction in bone mass or quality over 150 years ago. Since one disadvantage of a fracture-based definition is that diagnosis and treatment will be delayed when prevention is considered optimal treatment, an expert panel convened by the World Health Organisation (WHO) has suggested that both low bone mineral density (BMD) and fracture be combined in a stratified definition of osteoporosis
9781402087486
217-236
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Westlake, S.
19eaf960-38f5-4a78-90f3-283cff7e19b8
Harvey, N.
ce487fb4-d360-4aac-9d17-9466d6cba145
Dennison, E.
ee647287-edb4-4392-8361-e59fd505b1d1
2009
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Westlake, S.
19eaf960-38f5-4a78-90f3-283cff7e19b8
Harvey, N.
ce487fb4-d360-4aac-9d17-9466d6cba145
Dennison, E.
ee647287-edb4-4392-8361-e59fd505b1d1
Cooper, C., Westlake, S., Harvey, N. and Dennison, E.
(2009)
Developmental origins of osteoporotic fracture.
In,
Goldberg, Gail, Prentice, Andrew, Prentice, Ann, Filteau, Suzanne and Simondon, Kirsten
(eds.)
Breast-Feeding: Early Influences on Later Health.
(Advances in Experimental Medicine and Biology, 639)
Netherlands.
Springer, .
(doi:10.1007/978-1-4020-8749-3).
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Book Section
Abstract
Osteoporosis is a skeletal disorder characterised by low bone mass and micro-architectural deterioration of bone tissue with a consequent increase in bone fragility and susceptibility to fracture.1 It is a widespread condition, often unrecognised in clinical practice, which may have devastating health consequences through its association with fragility fractures. The term ‘osteoporosis’ was first used in the nineteenth century as a histologic description for aged bone tissue, but its clinical consequences were not appreciated until Sir Astley Cooper recognised that hip fractures might result from an age-related reduction in bone mass or quality over 150 years ago. Since one disadvantage of a fracture-based definition is that diagnosis and treatment will be delayed when prevention is considered optimal treatment, an expert panel convened by the World Health Organisation (WHO) has suggested that both low bone mineral density (BMD) and fracture be combined in a stratified definition of osteoporosis
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Published date: 2009
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Local EPrints ID: 68873
URI: http://eprints.soton.ac.uk/id/eprint/68873
ISBN: 9781402087486
ISSN: 0065-2598
PURE UUID: ae069519-bdb5-48e2-a8d6-794d7c57dfba
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Date deposited: 07 Oct 2009
Last modified: 18 Mar 2024 02:58
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Contributors
Author:
S. Westlake
Editor:
Gail Goldberg
Editor:
Andrew Prentice
Editor:
Ann Prentice
Editor:
Suzanne Filteau
Editor:
Kirsten Simondon
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