Volumetric bone density of the tibia is not increased in subjects with radiographic knee osteoarthritis
Abdin-Mohamed, M., Jameson, K., Dennison, E.M, Cooper, C. and Arden, N.K. (2009) Volumetric bone density of the tibia is not increased in subjects with radiographic knee osteoarthritis. Osteoarthritis and Cartilage, 17, (2), 174-177. (doi:10.1016/j.joca.2008.06.004).
Objectives: Radiographic osteoarthritis (ROA) has previously been shown to be associated with an increase in areal bone mineral density
(BMD) as assessed by dual energy X-ray absorptiometry (DXA). Here we have assessed volumetric bone density, size and strength by
peripheral quantitative computed tomography (pQCT) in a large population-based cohort study in which knee radiographs were available.
Methods: Two hundred and ninety-five men and 288 women from the MRC Hertfordshire Cohort Study underwent weight bearing extended
knee X-rays and bone density measurement of the ipsi-lateral knee using pQCT.
Results: Increasing radiographic grade in men but not women was associated with an increase in tibial total area at 38% site and cortical area
at 14% site, but not with volumetric BMD. The tibial fracture loads as well as tibial polar strength strain index at 38% site were also increased.
There were no significant associations of tibia bone area, BMD or strength with radiographic grade in women.
Conclusion: ROA is not associated with an increase in volumetric BMD as assessed by pQCT. It is, however, associated with a significant
increase in bone area and strength, indicating that the association between ROA and areal BMD is mediated through bone size rather
than volumetric BMD.
|Keywords:||bone strength, peripheral quantitative computerised tomography, bone geometry|
|Subjects:||R Medicine > RB Pathology
Q Science > QA Mathematics > QA75 Electronic computers. Computer science
Q Science > QP Physiology
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
|Date Deposited:||17 Nov 2009|
|Last Modified:||02 Mar 2012 12:14|
|Contact Email Address:||email@example.com|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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