Volumetric bone density of the tibia is not increased in subjects with radiographic knee osteoarthritis

Abdin-Mohamed, M., Jameson, K., Dennison, E.M, Cooper, C. and Arden, N.K. (2009) Volumetric bone density of the tibia is not increased in subjects with radiographic knee osteoarthritis. Osteoarthritis and Cartilage, 17, (2), 174-177. (doi:10.1016/j.joca.2008.06.004).


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Objectives: Radiographic osteoarthritis (ROA) has previously been shown to be associated with an increase in areal bone mineral density
(BMD) as assessed by dual energy X-ray absorptiometry (DXA). Here we have assessed volumetric bone density, size and strength by
peripheral quantitative computed tomography (pQCT) in a large population-based cohort study in which knee radiographs were available.

Methods: Two hundred and ninety-five men and 288 women from the MRC Hertfordshire Cohort Study underwent weight bearing extended
knee X-rays and bone density measurement of the ipsi-lateral knee using pQCT.

Results: Increasing radiographic grade in men but not women was associated with an increase in tibial total area at 38% site and cortical area
at 14% site, but not with volumetric BMD. The tibial fracture loads as well as tibial polar strength strain index at 38% site were also increased.
There were no significant associations of tibia bone area, BMD or strength with radiographic grade in women.

Conclusion: ROA is not associated with an increase in volumetric BMD as assessed by pQCT. It is, however, associated with a significant
increase in bone area and strength, indicating that the association between ROA and areal BMD is mediated through bone size rather
than volumetric BMD.

Item Type: Article
ISSNs: 1063-4584 (print)
Related URLs:
Keywords: bone strength, peripheral quantitative computerised tomography, bone geometry
Subjects: R Medicine > RB Pathology
Q Science > QA Mathematics > QA75 Electronic computers. Computer science
Q Science > QP Physiology
Divisions: University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
ePrint ID: 69448
Date Deposited: 17 Nov 2009
Last Modified: 27 Mar 2014 18:49
Contact Email Address: nka@mrc.soton.ac.uk
URI: http://eprints.soton.ac.uk/id/eprint/69448

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