Allelic association: linkage disequilibrium structure and gene mapping
Allelic association: linkage disequilibrium structure and gene mapping
The linkage disequilibrium (LD) structure of the human genome is now well understood and characterised for a number of human populations. The LD structure underpins the design and execution of candidate gene and genome-wide association mapping studies. Successful association mapping studies completed to date provide vital new insights into the genetic influences on common diseases, such as diabetes, some cancers and heart disease. The LD structure also presents new avenues of research into the genetic history of human populations, the effects of natural selection and the impact of recombination on the genomic landscape. This review introduces this exciting and complex field by encompassing this range of topics
genetic linkage, linkage disequilibrium, association mapping, natural selection, genome-wide association
83-89
Collins, Andrew
7daa83eb-0b21-43b2-af1a-e38fb36e2a64
January 2009
Collins, Andrew
7daa83eb-0b21-43b2-af1a-e38fb36e2a64
Abstract
The linkage disequilibrium (LD) structure of the human genome is now well understood and characterised for a number of human populations. The LD structure underpins the design and execution of candidate gene and genome-wide association mapping studies. Successful association mapping studies completed to date provide vital new insights into the genetic influences on common diseases, such as diabetes, some cancers and heart disease. The LD structure also presents new avenues of research into the genetic history of human populations, the effects of natural selection and the impact of recombination on the genomic landscape. This review introduces this exciting and complex field by encompassing this range of topics
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Published date: January 2009
Keywords:
genetic linkage, linkage disequilibrium, association mapping, natural selection, genome-wide association
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Local EPrints ID: 69558
URI: http://eprints.soton.ac.uk/id/eprint/69558
ISSN: 1073-6085
PURE UUID: 6a8d288e-7a78-4adc-9347-981c4d1aab43
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Date deposited: 18 Nov 2009
Last modified: 14 Mar 2024 02:35
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