Approaches to the identification of susceptibility genes
Approaches to the identification of susceptibility genes
Although previous studies have revealed a great deal about the genetic basis of susceptibility and resistance to parasite infection, there is now an opportunity to considerably enhance understanding through genome-wide association mapping. The application of association mapping to complex inheritance has recently become achievable given reduced costs, sophisticated genotyping platforms and powerful statistical methods which build upon increased knowledge of the linkage disequilibrium structure of the human genome. Linkage mapping and related approaches remain useful for the localization of the rarer genetic variants and candidate region association studies can be a very cost-effective route to progress. However, genome-wide association offers the greatest promise, despite the challenges posed by phenotype complexity, ensuring genotype coverage/quality and robust statistical analysis. The available approaches for mapping genes underlying susceptibility are reviewed here, emphasizing their relative merits and drawbacks and highlighting specific software tools and resources that enable successful mapping
parasite susceptibility genes, segregation analysis, linkage mapping, linkage disequilibrium, association mapping, quality control, software and web resources
225-233
Collins, A.
7daa83eb-0b21-43b2-af1a-e38fb36e2a64
May 2009
Collins, A.
7daa83eb-0b21-43b2-af1a-e38fb36e2a64
Abstract
Although previous studies have revealed a great deal about the genetic basis of susceptibility and resistance to parasite infection, there is now an opportunity to considerably enhance understanding through genome-wide association mapping. The application of association mapping to complex inheritance has recently become achievable given reduced costs, sophisticated genotyping platforms and powerful statistical methods which build upon increased knowledge of the linkage disequilibrium structure of the human genome. Linkage mapping and related approaches remain useful for the localization of the rarer genetic variants and candidate region association studies can be a very cost-effective route to progress. However, genome-wide association offers the greatest promise, despite the challenges posed by phenotype complexity, ensuring genotype coverage/quality and robust statistical analysis. The available approaches for mapping genes underlying susceptibility are reviewed here, emphasizing their relative merits and drawbacks and highlighting specific software tools and resources that enable successful mapping
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Published date: May 2009
Keywords:
parasite susceptibility genes, segregation analysis, linkage mapping, linkage disequilibrium, association mapping, quality control, software and web resources
Identifiers
Local EPrints ID: 69559
URI: http://eprints.soton.ac.uk/id/eprint/69559
ISSN: 0141-9838
PURE UUID: 208f9e71-9f37-41f7-9570-da15a8a78e72
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Date deposited: 18 Nov 2009
Last modified: 14 Mar 2024 02:35
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