3-Penten-2-one, a novel aldehyde adduct, is a biomarker for increased acetaldehyde in urine
Walker, Valerie, Mills, Graham A. and Standsbridge, Elizabeth M. (2009) 3-Penten-2-one, a novel aldehyde adduct, is a biomarker for increased acetaldehyde in urine. Journal of Chromatography B, 877, (8-9), 784-790. (doi:10.1016/j.jchromb.2009.02.017).
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Diagnostic profiling of urine for volatile compounds of around 400 patients using headspace solid-phase microextraction (HS-SPME) in alkaline conditions identified 3-penten-2-one (approximately 1 to >6.3 μmol/L) in 26 patients. Five were in barbiturate coma. 3-Penten-2-one, previously of unknown origin, was shown to be formed by aldol condensation of acetaldehyde with acetone or acetoacetate during analysis. Semi-quantification of acetaldehyde using in-fibre derivatisation HS-SPME, showed high concentrations in five urine (33–348 μmol/L) and two plasma (17 and 43 μmol/L) samples. Hence, urinary 3-penten-2-one is a useful biomarker for increased accumulation of acetaldehyde during abnormal metabolic stress
|Keywords:||3-penten-2-one, acetaldehyde, aldehydes, ALDH2, biological fluids, biomarker, solid-phase microextraction|
|Subjects:||Q Science > QH Natural history > QH426 Genetics|
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Human Genetics
|Date Deposited:||24 Nov 2009|
|Last Modified:||23 Jul 2012 00:06|
|Contributors:||Walker, Valerie (Author)
Mills, Graham A. (Author)
Standsbridge, Elizabeth M. (Author)
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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