3-Penten-2-one, a novel aldehyde adduct, is a biomarker for increased acetaldehyde in urine
Walker, Valerie, Mills, Graham A. and Standsbridge, Elizabeth M. (2009) 3-Penten-2-one, a novel aldehyde adduct, is a biomarker for increased acetaldehyde in urine. Journal of Chromatography B, 877, (8-9), 784-790. (doi:10.1016/j.jchromb.2009.02.017).
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Description/Abstract
Diagnostic profiling of urine for volatile compounds of around 400 patients using headspace solid-phase microextraction (HS-SPME) in alkaline conditions identified 3-penten-2-one (approximately 1 to >6.3 μmol/L) in 26 patients. Five were in barbiturate coma. 3-Penten-2-one, previously of unknown origin, was shown to be formed by aldol condensation of acetaldehyde with acetone or acetoacetate during analysis. Semi-quantification of acetaldehyde using in-fibre derivatisation HS-SPME, showed high concentrations in five urine (33–348 μmol/L) and two plasma (17 and 43 μmol/L) samples. Hence, urinary 3-penten-2-one is a useful biomarker for increased accumulation of acetaldehyde during abnormal metabolic stress
| Item Type: | Article |
|---|---|
| ISSNs: | 1570-0232 (print) |
| Related URLs: | |
| Keywords: | 3-penten-2-one, acetaldehyde, aldehydes, ALDH2, biological fluids, biomarker, solid-phase microextraction |
| Subjects: | Q Science > QH Natural history > QH426 Genetics |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Human Genetics |
| Item ID: | 69650 |
| Date Deposited: | 24 Nov 2009 |
| Last Modified: | 23 Jul 2012 00:06 |
| Contributors: | Walker, Valerie (Author) Mills, Graham A. (Author) Standsbridge, Elizabeth M. (Author) |
| Date: | March 2009 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/69650 |
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