17q21 Variants and asthma - questions and answers
17q21 Variants and asthma - questions and answers
It has long been established that many common diseases are the result of interactions between genetic susceptibility and environmental exposure. The identification of genetic variants that underlie susceptibility to diseases and alter the expression or function of proteins (either familiar or novel) can implicate the protein in question in the pathogenesis of the disease. This not only increases the understanding of disease pathophysiology but also can lead to the development of new therapeutic agents. It is this hope that has spurred the search for genetic variants underlying common diseases during the past quarter century.
2043-2045
Holloway, J.W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Koppelman, G.H.
ac555bcf-645d-4e63-b8be-387ffc69ad34
November 2008
Holloway, J.W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Koppelman, G.H.
ac555bcf-645d-4e63-b8be-387ffc69ad34
Holloway, J.W. and Koppelman, G.H.
(2008)
17q21 Variants and asthma - questions and answers.
New England Journal of Medicine, 359 (19), .
(doi:10.1056/NEJMe0807576).
Abstract
It has long been established that many common diseases are the result of interactions between genetic susceptibility and environmental exposure. The identification of genetic variants that underlie susceptibility to diseases and alter the expression or function of proteins (either familiar or novel) can implicate the protein in question in the pathogenesis of the disease. This not only increases the understanding of disease pathophysiology but also can lead to the development of new therapeutic agents. It is this hope that has spurred the search for genetic variants underlying common diseases during the past quarter century.
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Published date: November 2008
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Local EPrints ID: 69839
URI: http://eprints.soton.ac.uk/id/eprint/69839
PURE UUID: b09f6b22-d314-430e-a7a4-8fd578e901ab
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Date deposited: 08 Dec 2009
Last modified: 14 Mar 2024 02:41
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Author:
G.H. Koppelman
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