The University of Southampton
×
Filter your search:
University of Southampton Institutional Repository

Genome-wide association scan meta-analysis identifies three loci influencing adiposity and fat distribution

Genome-wide association scan meta-analysis identifies three loci influencing adiposity and fat distribution
Genome-wide association scan meta-analysis identifies three loci influencing adiposity and fat distribution
To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist–hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of association with measures of central adiposity (WC and/or WHR) was strong and disproportionate to that for overall adiposity or height. Follow-up studies in a maximum of 70,689 individuals identified two loci strongly associated with measures of central adiposity; these map near TFAP2B (WC, P = 1.9×10?11) and MSRA (WC, P = 8.9×10?9). A third locus, near LYPLAL1, was associated with WHR in women only (P = 2.6×10?8). The variants near TFAP2B appear to influence central adiposity through an effect on overall obesity/fat-mass, whereas LYPLAL1 displays a strong female-only association with fat distribution. By focusing on anthropometric measures of central obesity and fat distribution, we have identified three loci implicated in the regulation of human adiposity
1553-7390
e1000508-[13pp]
Lindgren, C.M.
6f47deda-4f5d-45f0-a7c9-c806824d21d5
Heid, I.M.
c19b3560-86c2-4b5f-a70e-04fec0a631e0
Randall, J.C.
f5a3b705-e291-4eb7-b244-3c75242a2519
Lamina, C.
82e798e3-f4a6-46af-90a4-73e806cbd041
Steinthorsdottir, V.
14d4da46-3669-485d-a37f-ce20dd80e2f1
Qi, L.
d1312bc6-c7fc-45e0-b75d-baaf78babbc1
Speliotes, E.K.
abfc51f9-5041-4a2e-8c7c-d8e1a985af67
Thorleifsson, G.
07a6ac27-e260-4070-b6a6-bd004666cb95
Willer, C.J.
16bce850-d5ca-488b-bf83-79cf741994d5
Herrera, B.M.
e12e25af-4e20-477a-9fca-e00782f9c70a
Jackson, A.U.
cebefb76-f243-413a-a3e8-19e4436fcb6e
Lim, N.
56072db7-9498-4cf1-b8ff-bd5bfbe70122
Scheet, P.
2f2ff4a6-07c9-443d-ae75-d7662d56a14a
Soranzo, N.
41734bbe-1f9e-4e91-b93b-96713059c6e0
Amin, N.
270db2aa-1880-4bab-b400-8e887415ab1f
Aulchenko, Y.S.
d2d7c92b-c013-4fb1-b998-aaabb8f80c45
Chambers, J.C.
ac7c5f4e-a8b1-495e-9f4a-dd212bc7cd13
Drong, A.
224cbbc4-f266-45f0-8dfa-0be0bff2d613
Luan, J.
3e375ba4-8172-490d-a325-952a118eda53
Lyon, H.N.
37d923e0-7f71-465c-8509-9643d48093a5
Rivadeneira, F.
642dbd8d-88a9-469d-826c-b75280f5620d
Sanna, S.
f4e595a5-ec49-4e46-932f-5c7c4d32baf4
Timpson, N.J.
757b845f-0901-431a-abc1-786d22646e9e
Zillikens, M.C.
bde3e816-1d53-4371-95a7-a4ed4a20a4ee
Zhao, J.H.
0cc29624-5ed3-42b8-8371-abc09f3d5b77
Almgren, P.
076e8a96-8884-4c37-ac56-c74fed6a9ae6
Bandinelli, S.
c1ab0b8d-df7b-4595-9b44-db255aac1b3e
Bennett, A.J.
3870a403-b5f8-4c7b-a5ad-923250378ae5
Bergman, R.N.
ae108329-e3c8-40b4-a66b-4fc067f346b6
Bonnycastle, L.L.
ab8e1d59-fdf1-4073-905b-473692c16b16
Bumpstead, S.J.
eb231886-30bc-4d41-b897-156e5e14baca
Chanock, S.J.
448f2ebe-33f1-4692-9c9f-92dc38e3612a
Cherkas, L.
75d357d0-fefa-42d5-a07c-e03c65ed0c07
Chines, P.
f37b4f9a-2292-4637-a959-6a5238a63feb
Coin, L.
c5d53891-0f8f-46e2-983a-6f50e6fb435b
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Crawford, G.
fb95b1e2-1f54-4d99-9e7d-5a5c899d8542
Doering, A.
144d0fc7-9d02-47d4-886f-3fba10db872c
Dominiczak, A.
4acb8616-9f2e-4581-86e8-67646f610915
Doney, A.S.
5e8a15bb-d06e-47c1-b7b2-c12ededcd9ae
Ebrahim, S.
cc462d6d-f796-479f-8126-7a48fcb965d4
Elliott, P.
d637af98-1c5a-43c7-913c-4b04d3824d9d
Erdos, M.R.
3b7c0974-febb-496f-8f5a-6ebd466a2f2f
Estrada, K.
77b24d52-0f3d-40fe-8b05-7eaac1b693d4
Ferrucci, L.
e01ada24-1b8c-43b8-8992-8d1e770c31e0
Fischer, G.
97f55b2c-abb8-42bc-a3a9-132e85c06071
Forouhi, N.G.
d2143411-7ddf-48a9-9c89-0035bcf4f2da
Gieger, C.
557ea762-6e93-4904-be0f-e3d3fd017bd0
Grallert, H.
69064c3c-59b4-446d-b74d-0917ae12edd6
Holloway, J.W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Wellcome Trust Case Control Consortium
Lindgren, C.M.
6f47deda-4f5d-45f0-a7c9-c806824d21d5
Heid, I.M.
c19b3560-86c2-4b5f-a70e-04fec0a631e0
Randall, J.C.
f5a3b705-e291-4eb7-b244-3c75242a2519
Lamina, C.
82e798e3-f4a6-46af-90a4-73e806cbd041
Steinthorsdottir, V.
14d4da46-3669-485d-a37f-ce20dd80e2f1
Qi, L.
d1312bc6-c7fc-45e0-b75d-baaf78babbc1
Speliotes, E.K.
abfc51f9-5041-4a2e-8c7c-d8e1a985af67
Thorleifsson, G.
07a6ac27-e260-4070-b6a6-bd004666cb95
Willer, C.J.
16bce850-d5ca-488b-bf83-79cf741994d5
Herrera, B.M.
e12e25af-4e20-477a-9fca-e00782f9c70a
Jackson, A.U.
cebefb76-f243-413a-a3e8-19e4436fcb6e
Lim, N.
56072db7-9498-4cf1-b8ff-bd5bfbe70122
Scheet, P.
2f2ff4a6-07c9-443d-ae75-d7662d56a14a
Soranzo, N.
41734bbe-1f9e-4e91-b93b-96713059c6e0
Amin, N.
270db2aa-1880-4bab-b400-8e887415ab1f
Aulchenko, Y.S.
d2d7c92b-c013-4fb1-b998-aaabb8f80c45
Chambers, J.C.
ac7c5f4e-a8b1-495e-9f4a-dd212bc7cd13
Drong, A.
224cbbc4-f266-45f0-8dfa-0be0bff2d613
Luan, J.
3e375ba4-8172-490d-a325-952a118eda53
Lyon, H.N.
37d923e0-7f71-465c-8509-9643d48093a5
Rivadeneira, F.
642dbd8d-88a9-469d-826c-b75280f5620d
Sanna, S.
f4e595a5-ec49-4e46-932f-5c7c4d32baf4
Timpson, N.J.
757b845f-0901-431a-abc1-786d22646e9e
Zillikens, M.C.
bde3e816-1d53-4371-95a7-a4ed4a20a4ee
Zhao, J.H.
0cc29624-5ed3-42b8-8371-abc09f3d5b77
Almgren, P.
076e8a96-8884-4c37-ac56-c74fed6a9ae6
Bandinelli, S.
c1ab0b8d-df7b-4595-9b44-db255aac1b3e
Bennett, A.J.
3870a403-b5f8-4c7b-a5ad-923250378ae5
Bergman, R.N.
ae108329-e3c8-40b4-a66b-4fc067f346b6
Bonnycastle, L.L.
ab8e1d59-fdf1-4073-905b-473692c16b16
Bumpstead, S.J.
eb231886-30bc-4d41-b897-156e5e14baca
Chanock, S.J.
448f2ebe-33f1-4692-9c9f-92dc38e3612a
Cherkas, L.
75d357d0-fefa-42d5-a07c-e03c65ed0c07
Chines, P.
f37b4f9a-2292-4637-a959-6a5238a63feb
Coin, L.
c5d53891-0f8f-46e2-983a-6f50e6fb435b
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Crawford, G.
fb95b1e2-1f54-4d99-9e7d-5a5c899d8542
Doering, A.
144d0fc7-9d02-47d4-886f-3fba10db872c
Dominiczak, A.
4acb8616-9f2e-4581-86e8-67646f610915
Doney, A.S.
5e8a15bb-d06e-47c1-b7b2-c12ededcd9ae
Ebrahim, S.
cc462d6d-f796-479f-8126-7a48fcb965d4
Elliott, P.
d637af98-1c5a-43c7-913c-4b04d3824d9d
Erdos, M.R.
3b7c0974-febb-496f-8f5a-6ebd466a2f2f
Estrada, K.
77b24d52-0f3d-40fe-8b05-7eaac1b693d4
Ferrucci, L.
e01ada24-1b8c-43b8-8992-8d1e770c31e0
Fischer, G.
97f55b2c-abb8-42bc-a3a9-132e85c06071
Forouhi, N.G.
d2143411-7ddf-48a9-9c89-0035bcf4f2da
Gieger, C.
557ea762-6e93-4904-be0f-e3d3fd017bd0
Grallert, H.
69064c3c-59b4-446d-b74d-0917ae12edd6
Holloway, J.W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a

Lindgren, C.M., Heid, I.M., Randall, J.C., Lamina, C., Steinthorsdottir, V., Qi, L., Speliotes, E.K., Thorleifsson, G., Willer, C.J., Herrera, B.M., Jackson, A.U., Lim, N., Scheet, P., Soranzo, N., Amin, N., Aulchenko, Y.S., Chambers, J.C., Drong, A., Luan, J., Lyon, H.N., Rivadeneira, F., Sanna, S., Timpson, N.J., Zillikens, M.C., Zhao, J.H., Almgren, P., Bandinelli, S., Bennett, A.J., Bergman, R.N., Bonnycastle, L.L., Bumpstead, S.J., Chanock, S.J., Cherkas, L., Chines, P., Coin, L., Cooper, C., Crawford, G., Doering, A., Dominiczak, A., Doney, A.S., Ebrahim, S., Elliott, P., Erdos, M.R., Estrada, K., Ferrucci, L., Fischer, G., Forouhi, N.G., Gieger, C., Grallert, H. and Holloway, J.W. , Wellcome Trust Case Control Consortium (2009) Genome-wide association scan meta-analysis identifies three loci influencing adiposity and fat distribution. PLoS Genetics, 5 (6), e1000508-[13pp]. (doi:10.1371/journal.pgen.1000508).

Record type: Article

Abstract

To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist–hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of association with measures of central adiposity (WC and/or WHR) was strong and disproportionate to that for overall adiposity or height. Follow-up studies in a maximum of 70,689 individuals identified two loci strongly associated with measures of central adiposity; these map near TFAP2B (WC, P = 1.9×10?11) and MSRA (WC, P = 8.9×10?9). A third locus, near LYPLAL1, was associated with WHR in women only (P = 2.6×10?8). The variants near TFAP2B appear to influence central adiposity through an effect on overall obesity/fat-mass, whereas LYPLAL1 displays a strong female-only association with fat distribution. By focusing on anthropometric measures of central obesity and fat distribution, we have identified three loci implicated in the regulation of human adiposity

Text
journal.pgen.1000508.pdf - Version of Record
Download (596kB)

More information

Published date: June 2009

Identifiers

Local EPrints ID: 69842
URI: http://eprints.soton.ac.uk/id/eprint/69842
DOI: doi:10.1371/journal.pgen.1000508
ISSN: 1553-7390
PURE UUID: 8fdeccf5-30c2-42b5-b656-69b740f4ef4a
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709
ORCID for J.W. Holloway: ORCID iD orcid.org/0000-0001-9998-0464

Catalogue record

Date deposited: 08 Dec 2009
Last modified: 19 Mar 2024 02:35

Export record

Altmetrics

Contributors

Author: C.M. Lindgren
Author: I.M. Heid
Author: J.C. Randall
Author: C. Lamina
Author: V. Steinthorsdottir
Author: L. Qi
Author: E.K. Speliotes
Author: G. Thorleifsson
Author: C.J. Willer
Author: B.M. Herrera
Author: A.U. Jackson
Author: N. Lim
Author: P. Scheet
Author: N. Soranzo
Author: N. Amin
Author: Y.S. Aulchenko
Author: J.C. Chambers
Author: A. Drong
Author: J. Luan
Author: H.N. Lyon
Author: F. Rivadeneira
Author: S. Sanna
Author: N.J. Timpson
Author: M.C. Zillikens
Author: J.H. Zhao
Author: P. Almgren
Author: S. Bandinelli
Author: A.J. Bennett
Author: R.N. Bergman
Author: L.L. Bonnycastle
Author: S.J. Bumpstead
Author: S.J. Chanock
Author: L. Cherkas
Author: P. Chines
Author: L. Coin
Author: C. Cooper ORCID iD
Author: G. Crawford
Author: A. Doering
Author: A. Dominiczak
Author: A.S. Doney
Author: S. Ebrahim
Author: P. Elliott
Author: M.R. Erdos
Author: K. Estrada
Author: L. Ferrucci
Author: G. Fischer
Author: N.G. Forouhi
Author: C. Gieger
Author: H. Grallert
Author: J.W. Holloway ORCID iD
Corporate Author: Wellcome Trust Case Control Consortium

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Library staff additional information
Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×