The University of Southampton
University of Southampton Institutional Repository

Standardisation of molecular monitoring for chronic myeloid leukaemia

Standardisation of molecular monitoring for chronic myeloid leukaemia
Standardisation of molecular monitoring for chronic myeloid leukaemia
Molecular monitoring of chronic myeloid leukaemia (CML) patients by real time quantitative reverse transcriptase PCR (RQ-PCR) is of clinical value, but the use of diverse laboratory protocols and units of measurement make it difficult to compare results between and sometimes within centres. This review explores the intrinsic difficulties in standardising the RQ-PCR analysis, summarises the progress that has been made following the proposal for a new International Scale for BCR-ABL measurement and discusses how further improvements are likely to be made.
BCR-ABL, real time PCR, international scale, minimal residual disease
1521-6926
355-365
Cross, Nicholas C.P.
f87650da-b908-4a34-b31b-d62c5f186fe4
Cross, Nicholas C.P.
f87650da-b908-4a34-b31b-d62c5f186fe4

Cross, Nicholas C.P. (2009) Standardisation of molecular monitoring for chronic myeloid leukaemia. Best Practice and Research Clinical Haematology, 22 (3), 355-365. (doi:10.1016/j.beha.2009.04.001).

Record type: Article

Abstract

Molecular monitoring of chronic myeloid leukaemia (CML) patients by real time quantitative reverse transcriptase PCR (RQ-PCR) is of clinical value, but the use of diverse laboratory protocols and units of measurement make it difficult to compare results between and sometimes within centres. This review explores the intrinsic difficulties in standardising the RQ-PCR analysis, summarises the progress that has been made following the proposal for a new International Scale for BCR-ABL measurement and discusses how further improvements are likely to be made.

This record has no associated files available for download.

More information

Published date: September 2009
Keywords: BCR-ABL, real time PCR, international scale, minimal residual disease

Identifiers

Local EPrints ID: 69866
URI: http://eprints.soton.ac.uk/id/eprint/69866
ISSN: 1521-6926
PURE UUID: 29ba1e1e-3f07-449a-8b56-b6c3ed21cd35
ORCID for Nicholas C.P. Cross: ORCID iD orcid.org/0000-0001-5481-2555

Catalogue record

Date deposited: 08 Dec 2009
Last modified: 14 Mar 2024 02:46

Export record

Altmetrics

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×