Standardisation of molecular monitoring for chronic myeloid leukaemia
Cross, Nicholas C.P. (2009) Standardisation of molecular monitoring for chronic myeloid leukaemia. Best Practice and Research. Clinical Haematology, 22, (3), 355-365. (doi:10.1016/j.beha.2009.04.001)
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Official URL: http://dx.doi.org/10.1016/j.beha.2009.04.001
Description/Abstract
Molecular monitoring of chronic myeloid leukaemia (CML) patients by real time quantitative reverse transcriptase PCR (RQ-PCR) is of clinical value, but the use of diverse laboratory protocols and units of measurement make it difficult to compare results between and sometimes within centres. This review explores the intrinsic difficulties in standardising the RQ-PCR analysis, summarises the progress that has been made following the proposal for a new International Scale for BCR-ABL measurement and discusses how further improvements are likely to be made.
| Item Type: | Article |
|---|---|
| ISSN: | 1521-6926 (print) |
| Uncontrolled Keywords: | BCR-ABL, real time PCR, international scale, minimal residual disease |
| Related URLs: | http://www.sciencedirect.com/s...rticle.pdf http://www.ncbi.nlm.nih.gov/pu...d/19959086 http://dx.doi.org/10.1016/j.be...009.04.001 |
| Subjects: | R Medicine > R Medicine (General) Q Science > QH Natural history > QH426 Genetics |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Human Genetics |
| ePrint ID: | 69866 |
| Deposited On: | 08 Dec 2009 |
| Last Modified: | 01 Jun 2011 08:31 |
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