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Newly discovered breast cancer susceptibility loci in 3p24 and 17q23.2

Newly discovered breast cancer susceptibility loci in 3p24 and 17q23.2
Newly discovered breast cancer susceptibility loci in 3p24 and 17q23.2
Genome-wide association studies (GWAS) have identified seven breast cancer susceptibility loci, but these explain only a small fraction of the familial risk of the disease. Five of these loci were identified through a two-stage GWAS involving 390 familial cases and 364 controls in the first stage, and 3,990 cases and 3,916 controls in the second stage1. To identify additional loci, we tested over 800 promising associations from this GWAS in a further two stages involving 37,012 cases and 40,069 controls from 33 studies in the CGEMS collaboration and Breast Cancer Association Consortium. We found strong evidence for additional susceptibility loci on 3p (rs4973768: per-allele OR = 1.11, 95% CI = 1.08–1.13, P = 4.1 times 10-23) and 17q (rs6504950: per-allele OR = 0.95, 95% CI = 0.92–0.97, P = 1.4 times 10-8). Potential causative genes include SLC4A7 and NEK10 on 3p and COX11 on 17q
1061-4036
585-590
Ahmed, S.
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Ghoussaini, M.
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Healey, C.S.
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Humphreys, M.K.
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Platte, R.
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Morrison, J.
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Maranian, M.
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Pooley, K.A.
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Luben, R.
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Eccles, D.
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Evans, D.G.
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Fletcher, O.
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Johnson, N.
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dos Santos Silva, I.
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Rahman, N.
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Bojesen, S.
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Nordestgaard, B.G.
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Schurmann, P.
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Hillemanns, P.
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Karstens, J.H.
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Bogdanova, N.V.
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Antonenkova, N.N.
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Zalutsky, I.V.
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Bermisheva, M.
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Fedorova, S.
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Khusnutdinova, E.
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Kang, D.
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Noh, D.Y.
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Ahn, S.H.
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Devilee, P.
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van Asperen, C.J.
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Tollenaar, R.S.
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SEARCH
Ahmed, S.
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Ghoussaini, M.
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Healey, C.S.
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Humphreys, M.K.
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Platte, R.
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Morrison, J.
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Maranian, M.
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Pooley, K.A.
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Luben, R.
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Eccles, D.
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Evans, D.G.
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Fletcher, O.
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Johnson, N.
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dos Santos Silva, I.
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Peto, J.
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Stratton, M.R.
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Rahman, N.
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Jacobs, K.
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Prentice, R.
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Anderson, G.L.
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Rajkovic, A.
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Curb, J.D.
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Ziegler, R.G.
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Berg, C.D.
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Buys, S.S.
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McCarthy, C.A.
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Feigelson, H.S.
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Calle, E.E.
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Thun, M.J.
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Diver, W.R.
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Bojesen, S.
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Nordestgaard, B.G.
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Flyger, H.
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Dork, T.
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Schurmann, P.
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Hillemanns, P.
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Karstens, J.H.
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Bogdanova, N.V.
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Antonenkova, N.N.
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Zalutsky, I.V.
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Bermisheva, M.
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Fedorova, S.
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Khusnutdinova, E.
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Kang, D.
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Yoo, K.Y.
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Noh, D.Y.
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Ahn, S.H.
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Devilee, P.
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van Asperen, C.J.
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Tollenaar, R.S.
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Ahmed, S., Ghoussaini, M., Healey, C.S., Humphreys, M.K., Platte, R., Morrison, J., Maranian, M., Pooley, K.A., Luben, R., Eccles, D., Evans, D.G., Fletcher, O., Johnson, N., dos Santos Silva, I., Peto, J., Stratton, M.R., Rahman, N., Jacobs, K., Prentice, R., Anderson, G.L., Rajkovic, A., Curb, J.D., Ziegler, R.G., Berg, C.D., Buys, S.S., McCarthy, C.A., Feigelson, H.S., Calle, E.E., Thun, M.J., Diver, W.R., Bojesen, S., Nordestgaard, B.G., Flyger, H., Dork, T., Schurmann, P., Hillemanns, P., Karstens, J.H., Bogdanova, N.V., Antonenkova, N.N., Zalutsky, I.V., Bermisheva, M., Fedorova, S., Khusnutdinova, E., Kang, D., Yoo, K.Y., Noh, D.Y., Ahn, S.H., Devilee, P., van Asperen, C.J. and Tollenaar, R.S. , SEARCH (2009) Newly discovered breast cancer susceptibility loci in 3p24 and 17q23.2. Nature Genetics, 41 (5), 585-590. (doi:10.1038/ng.354). (PMID:19330027)

Record type: Article

Abstract

Genome-wide association studies (GWAS) have identified seven breast cancer susceptibility loci, but these explain only a small fraction of the familial risk of the disease. Five of these loci were identified through a two-stage GWAS involving 390 familial cases and 364 controls in the first stage, and 3,990 cases and 3,916 controls in the second stage1. To identify additional loci, we tested over 800 promising associations from this GWAS in a further two stages involving 37,012 cases and 40,069 controls from 33 studies in the CGEMS collaboration and Breast Cancer Association Consortium. We found strong evidence for additional susceptibility loci on 3p (rs4973768: per-allele OR = 1.11, 95% CI = 1.08–1.13, P = 4.1 times 10-23) and 17q (rs6504950: per-allele OR = 0.95, 95% CI = 0.92–0.97, P = 1.4 times 10-8). Potential causative genes include SLC4A7 and NEK10 on 3p and COX11 on 17q

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More information

Published date: May 2009
Organisations: Cancer Sciences, Clinical Trials Unit

Identifiers

Local EPrints ID: 69918
URI: http://eprints.soton.ac.uk/id/eprint/69918
DOI: doi:10.1038/ng.354
ISSN: 1061-4036
PURE UUID: 5446fcae-3fd0-4c5e-b41e-0f722a5da1ab
ORCID for D. Eccles: ORCID iD orcid.org/0000-0002-9935-3169

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Date deposited: 10 Dec 2009
Last modified: 14 Mar 2024 02:34

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Contributors

Author: S. Ahmed
Author: M. Ghoussaini
Author: C.S. Healey
Author: M.K. Humphreys
Author: R. Platte
Author: J. Morrison
Author: M. Maranian
Author: K.A. Pooley
Author: R. Luben
Author: D. Eccles ORCID iD
Author: D.G. Evans
Author: O. Fletcher
Author: N. Johnson
Author: I. dos Santos Silva
Author: J. Peto
Author: M.R. Stratton
Author: N. Rahman
Author: K. Jacobs
Author: R. Prentice
Author: G.L. Anderson
Author: A. Rajkovic
Author: J.D. Curb
Author: R.G. Ziegler
Author: C.D. Berg
Author: S.S. Buys
Author: C.A. McCarthy
Author: H.S. Feigelson
Author: E.E. Calle
Author: M.J. Thun
Author: W.R. Diver
Author: S. Bojesen
Author: B.G. Nordestgaard
Author: H. Flyger
Author: T. Dork
Author: P. Schurmann
Author: P. Hillemanns
Author: J.H. Karstens
Author: N.V. Bogdanova
Author: N.N. Antonenkova
Author: I.V. Zalutsky
Author: M. Bermisheva
Author: S. Fedorova
Author: E. Khusnutdinova
Author: D. Kang
Author: K.Y. Yoo
Author: D.Y. Noh
Author: S.H. Ahn
Author: P. Devilee
Author: C.J. van Asperen
Author: R.S. Tollenaar
Corporate Author: SEARCH

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