Pro-neurogenic peptides and neurogenesis in the normal and seizure damaged hippocampus.
Gray, William (2008) Pro-neurogenic peptides and neurogenesis in the normal and seizure damaged hippocampus. In, 6th FENS Forum of European Neuroscience, Geneva, Switzerland, 12 - 16 Jul 2008.
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Description/Abstract
We have shown that neuropeptide Y (NPY), a peptide neurotransmitter released by hippocampal
interneurons, is proliferative via the Y1 receptor, for both nestin positive precursors and committed
neuroblasts in the normal dentate gyrus, and for nestin positive progenitors in the subventricular and
subcallosal stem cell niches around the hippocampus. Knockout studies also show that NPY and
FGF2 are individually necessary, but not sufficient, for seizure-induced precursor proliferation,
suggesting a possible interaction. In this presentation I will review the roles of NPY and other peptide
transmitters in the neural stem cell niche under normal conditions and after kainate-induced status
epilepticus, and will describe novel and important interactions between these neuropeptides and
FGF2
| Item Type: | Conference or Workshop Item (Paper) |
|---|---|
| Uncontrolled Keywords: | hippocampus, brain |
| Related URLs: | http://fens2008.neurosciences.asso.fr/ |
| Subjects: | R Medicine |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Clinical Neurosciences |
| ePrint ID: | 70145 |
| Deposited On: | 19 Mar 2010 |
| Last Modified: | 22 Dec 2010 01:09 |
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