Pro-neurogenic peptides and neurogenesis in the normal and seizure damaged hippocampus.
Pro-neurogenic peptides and neurogenesis in the normal and seizure damaged hippocampus.
We have shown that neuropeptide Y (NPY), a peptide neurotransmitter released by hippocampal
interneurons, is proliferative via the Y1 receptor, for both nestin positive precursors and committed
neuroblasts in the normal dentate gyrus, and for nestin positive progenitors in the subventricular and
subcallosal stem cell niches around the hippocampus. Knockout studies also show that NPY and
FGF2 are individually necessary, but not sufficient, for seizure-induced precursor proliferation,
suggesting a possible interaction. In this presentation I will review the roles of NPY and other peptide
transmitters in the neural stem cell niche under normal conditions and after kainate-induced status
epilepticus, and will describe novel and important interactions between these neuropeptides and
FGF2
hippocampus, brain
Gray, William
1d25fc21-c58d-4342-9264-e4f53e04f702
Malva, J.
4915872e-eaba-49c0-9c78-0416da91051f
Gray, W. P.
b6494778-072e-4b3d-ba25-f4f41f393109
12 July 2008
Gray, William
1d25fc21-c58d-4342-9264-e4f53e04f702
Malva, J.
4915872e-eaba-49c0-9c78-0416da91051f
Gray, W. P.
b6494778-072e-4b3d-ba25-f4f41f393109
Gray, William
(2008)
Pro-neurogenic peptides and neurogenesis in the normal and seizure damaged hippocampus.
Malva, J. and Gray, W. P.
(eds.)
6th FENS Forum of European Neuroscience, Geneva, Switzerland.
11 - 15 Jul 2008.
Record type:
Conference or Workshop Item
(Paper)
Abstract
We have shown that neuropeptide Y (NPY), a peptide neurotransmitter released by hippocampal
interneurons, is proliferative via the Y1 receptor, for both nestin positive precursors and committed
neuroblasts in the normal dentate gyrus, and for nestin positive progenitors in the subventricular and
subcallosal stem cell niches around the hippocampus. Knockout studies also show that NPY and
FGF2 are individually necessary, but not sufficient, for seizure-induced precursor proliferation,
suggesting a possible interaction. In this presentation I will review the roles of NPY and other peptide
transmitters in the neural stem cell niche under normal conditions and after kainate-induced status
epilepticus, and will describe novel and important interactions between these neuropeptides and
FGF2
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More information
Published date: 12 July 2008
Venue - Dates:
6th FENS Forum of European Neuroscience, Geneva, Switzerland, 2008-07-11 - 2008-07-15
Keywords:
hippocampus, brain
Identifiers
Local EPrints ID: 70145
URI: http://eprints.soton.ac.uk/id/eprint/70145
PURE UUID: a7d9d2d4-16ef-4b68-8858-35958789d96e
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Date deposited: 19 Mar 2010
Last modified: 10 Dec 2021 16:29
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Contributors
Author:
William Gray
Editor:
J. Malva
Editor:
W. P. Gray
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