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Pro-neurogenic peptides and neurogenesis in the normal and seizure damaged hippocampus.

Pro-neurogenic peptides and neurogenesis in the normal and seizure damaged hippocampus.
Pro-neurogenic peptides and neurogenesis in the normal and seizure damaged hippocampus.
We have shown that neuropeptide Y (NPY), a peptide neurotransmitter released by hippocampal interneurons, is proliferative via the Y1 receptor, for both nestin positive precursors and committed neuroblasts in the normal dentate gyrus, and for nestin positive progenitors in the subventricular and subcallosal stem cell niches around the hippocampus. Knockout studies also show that NPY and FGF2 are individually necessary, but not sufficient, for seizure-induced precursor proliferation, suggesting a possible interaction. In this presentation I will review the roles of NPY and other peptide transmitters in the neural stem cell niche under normal conditions and after kainate-induced status epilepticus, and will describe novel and important interactions between these neuropeptides and FGF2
hippocampus, brain
Gray, William
1d25fc21-c58d-4342-9264-e4f53e04f702
Malva, J.
4915872e-eaba-49c0-9c78-0416da91051f
Gray, W. P.
b6494778-072e-4b3d-ba25-f4f41f393109
Gray, William
1d25fc21-c58d-4342-9264-e4f53e04f702
Malva, J.
4915872e-eaba-49c0-9c78-0416da91051f
Gray, W. P.
b6494778-072e-4b3d-ba25-f4f41f393109

Gray, William (2008) Pro-neurogenic peptides and neurogenesis in the normal and seizure damaged hippocampus. Malva, J. and Gray, W. P. (eds.) 6th FENS Forum of European Neuroscience, Geneva, Switzerland. 11 - 15 Jul 2008.

Record type: Conference or Workshop Item (Paper)

Abstract

We have shown that neuropeptide Y (NPY), a peptide neurotransmitter released by hippocampal interneurons, is proliferative via the Y1 receptor, for both nestin positive precursors and committed neuroblasts in the normal dentate gyrus, and for nestin positive progenitors in the subventricular and subcallosal stem cell niches around the hippocampus. Knockout studies also show that NPY and FGF2 are individually necessary, but not sufficient, for seizure-induced precursor proliferation, suggesting a possible interaction. In this presentation I will review the roles of NPY and other peptide transmitters in the neural stem cell niche under normal conditions and after kainate-induced status epilepticus, and will describe novel and important interactions between these neuropeptides and FGF2

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More information

Published date: 12 July 2008
Venue - Dates: 6th FENS Forum of European Neuroscience, Geneva, Switzerland, 2008-07-11 - 2008-07-15
Keywords: hippocampus, brain

Identifiers

Local EPrints ID: 70145
URI: http://eprints.soton.ac.uk/id/eprint/70145
PURE UUID: a7d9d2d4-16ef-4b68-8858-35958789d96e

Catalogue record

Date deposited: 19 Mar 2010
Last modified: 10 Dec 2021 16:29

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Contributors

Author: William Gray
Editor: J. Malva
Editor: W. P. Gray

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