Auto-adjusting positive airway pressure in children with sickle cell anemia: results of a phase I randomized controlled trial
Auto-adjusting positive airway pressure in children with sickle cell anemia: results of a phase I randomized controlled trial
Low nocturnal oxygen saturation (SpO2) is implicated in complications of Sickle Cell Anemia (SCA). Twenty-four children with SCA were randomized to receive overnight auto-adjusting continuous positive airway pressure (auto-CPAP) with supplemental oxygen, if required, to maintain SpO2 94% or as controls. We assessed adherence, safety, sleep parameters, cognition and pain. Twelve participants randomized to auto-CPAP (3 with oxygen) showed improvement in Apnea/Hypopnea Index (p<0.001), average desaturation events >3%/hour (p=0.02), mean nocturnal SpO2 (p=0.02) and cognition. Primary efficacy endpoint (Processing Speed Index) showed no group differences (p=0.67), but a second measure of processing speed and attention (Cancellation) improved in those receiving treatment (p=0.01). No bone marrow suppression, rebound pain or serious adverse event resulting from auto-CPAP use was observed. Six weeks of auto-CPAP therapy is feasible and safe in children with SCA, significantly improving sleep-related breathing disorders and at least one aspect of cognition.
therapy, red cells, hemoglobinopathies, quality of life, continuous positive airway pressure, oxygen saturation
1006-1010
Marshall, Melanie J.
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Bucks, Romola S.
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Hogan, Alexandra M.
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Hambleton, Ian R.
013b991d-7fd6-4cd4-9cae-d4fef258656b
Height, Susan E.
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Dick, Moira C.
72eb0b31-f4a6-41bf-b395-92e512676ca6
Kirkham, Fenella J.
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Rees, David C.
8edfda69-3e13-4e7a-83b9-6bb2784f1968
2009
Marshall, Melanie J.
fe58e080-7009-4113-afcf-bdeb05394728
Bucks, Romola S.
95c31da3-2a01-45e7-a648-76d84a49edc4
Hogan, Alexandra M.
95ce4e2d-0f63-4ada-b43f-8f3a0c3b4a21
Hambleton, Ian R.
013b991d-7fd6-4cd4-9cae-d4fef258656b
Height, Susan E.
0ed7fb9e-6c9f-4d9a-a9e1-b1caa7a55622
Dick, Moira C.
72eb0b31-f4a6-41bf-b395-92e512676ca6
Kirkham, Fenella J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Rees, David C.
8edfda69-3e13-4e7a-83b9-6bb2784f1968
Marshall, Melanie J., Bucks, Romola S., Hogan, Alexandra M., Hambleton, Ian R., Height, Susan E., Dick, Moira C., Kirkham, Fenella J. and Rees, David C.
(2009)
Auto-adjusting positive airway pressure in children with sickle cell anemia: results of a phase I randomized controlled trial.
Haematologica, 94 (7), .
(doi:10.3324/haematol.2008.005215).
Abstract
Low nocturnal oxygen saturation (SpO2) is implicated in complications of Sickle Cell Anemia (SCA). Twenty-four children with SCA were randomized to receive overnight auto-adjusting continuous positive airway pressure (auto-CPAP) with supplemental oxygen, if required, to maintain SpO2 94% or as controls. We assessed adherence, safety, sleep parameters, cognition and pain. Twelve participants randomized to auto-CPAP (3 with oxygen) showed improvement in Apnea/Hypopnea Index (p<0.001), average desaturation events >3%/hour (p=0.02), mean nocturnal SpO2 (p=0.02) and cognition. Primary efficacy endpoint (Processing Speed Index) showed no group differences (p=0.67), but a second measure of processing speed and attention (Cancellation) improved in those receiving treatment (p=0.01). No bone marrow suppression, rebound pain or serious adverse event resulting from auto-CPAP use was observed. Six weeks of auto-CPAP therapy is feasible and safe in children with SCA, significantly improving sleep-related breathing disorders and at least one aspect of cognition.
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Published date: 2009
Keywords:
therapy, red cells, hemoglobinopathies, quality of life, continuous positive airway pressure, oxygen saturation
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Local EPrints ID: 70202
URI: http://eprints.soton.ac.uk/id/eprint/70202
ISSN: 0390-6078
PURE UUID: a9aa134e-ba62-4bcf-8220-4880437a8da0
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Date deposited: 11 Dec 2009
Last modified: 14 Mar 2024 02:45
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Contributors
Author:
Melanie J. Marshall
Author:
Romola S. Bucks
Author:
Alexandra M. Hogan
Author:
Ian R. Hambleton
Author:
Susan E. Height
Author:
Moira C. Dick
Author:
David C. Rees
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