Influence of ethnicity on IGF-I and procollagen III peptide (P-III-P) in elite athletes and its effect on the ability to detect GH abuse
Influence of ethnicity on IGF-I and procollagen III peptide (P-III-P) in elite athletes and its effect on the ability to detect GH abuse
CONTEXT: A method based on the two GH dependent markers, IGF-I and procollagen III peptide (P-III-P) has been proposed to detect exogenously administered GH. As previous studies involved predominantly white European elite athletes, it is necessary to validate the method in other ethnic groups. OBJECTIVE: To examine serum IGF-I and P-III-P in elite athletes of different ethnicities within 2 h of competing at national or international events. DESIGN: Cross-sectional observational study. SETTING: National and International sporting events. SUBJECTS: 1085 elite athletes of different ethnicities. INTERVENTION: Serum IGF-I and P-III-P were measured and GH-2000 discriminant function score was calculated. Effect of ethnicity was assessed. RESULTS: In men, IGF-I was 21.7 +/- 2.6% lower in Afro-Caribbeans than white Europeans (P < 0.0001) but there were no differences between other ethnic groups. In women, IGF-I was 14.2 +/- 5.1% lower in Afro-Caribbeans (P = 0.005) and 15.6 +/- 7.0% higher in Orientals (P = 0.02) compared with white Europeans. P-III-P was 15.2 +/- 3.5%, 26.6 +/- 6.6% and 19.3 +/- 5.8% lower in Afro-Caribbean (P < 0.0001), Indo-Asian (P < 0.0001) and Oriental men (P = 0.001), respectively, compared with white European men. In women, P-III-P was 15.7 +/- 4.7% lower in Afro-Caribbeans compared to white Europeans (P =0.0009) but there were no differences between other ethnicities. Despite these differences, most observations were below the upper 99% prediction limits derived from white European athletes. All GH-2000 scores lay below the cut-off limit proposed for doping. CONCLUSIONS: The GH-2000 detection method based on IGF-I and P-III-P would be valid in all ethnic groups
women, metabolism, prediction, disease, procollagen, ethnic groups, developmental origins, health, endocrinology
161-168
Erotokritou-Mulligan, Ioulietta
8bb8720a-eda7-4ad4-b969-0b35c5e5226c
Bassett, E. Eryl
fefd7f16-2045-4700-adaa-7cc6049933a4
Cowan, David A.
22bdafa8-cee8-481a-97d5-2687fcf325ca
Bartlett, Christiaan
ed9cba27-96ef-419e-824b-fabab5c7cba8
McHugh, Cathy
490395d5-8da7-4c97-a0de-51b7e7e2b35c
Sonksen, Peter H.
b3cf05ef-65c2-4e9b-8d95-b7c3aaf532cd
Holt, Richard I.G.
d54202e1-fcf6-4a17-a320-9f32d7024393
January 2009
Erotokritou-Mulligan, Ioulietta
8bb8720a-eda7-4ad4-b969-0b35c5e5226c
Bassett, E. Eryl
fefd7f16-2045-4700-adaa-7cc6049933a4
Cowan, David A.
22bdafa8-cee8-481a-97d5-2687fcf325ca
Bartlett, Christiaan
ed9cba27-96ef-419e-824b-fabab5c7cba8
McHugh, Cathy
490395d5-8da7-4c97-a0de-51b7e7e2b35c
Sonksen, Peter H.
b3cf05ef-65c2-4e9b-8d95-b7c3aaf532cd
Holt, Richard I.G.
d54202e1-fcf6-4a17-a320-9f32d7024393
Erotokritou-Mulligan, Ioulietta, Bassett, E. Eryl, Cowan, David A., Bartlett, Christiaan, McHugh, Cathy, Sonksen, Peter H. and Holt, Richard I.G.
(2009)
Influence of ethnicity on IGF-I and procollagen III peptide (P-III-P) in elite athletes and its effect on the ability to detect GH abuse.
Clinical Endocrinology, 70 (1), .
(doi:10.1111/j.1365-2265.2008.03319.x).
Abstract
CONTEXT: A method based on the two GH dependent markers, IGF-I and procollagen III peptide (P-III-P) has been proposed to detect exogenously administered GH. As previous studies involved predominantly white European elite athletes, it is necessary to validate the method in other ethnic groups. OBJECTIVE: To examine serum IGF-I and P-III-P in elite athletes of different ethnicities within 2 h of competing at national or international events. DESIGN: Cross-sectional observational study. SETTING: National and International sporting events. SUBJECTS: 1085 elite athletes of different ethnicities. INTERVENTION: Serum IGF-I and P-III-P were measured and GH-2000 discriminant function score was calculated. Effect of ethnicity was assessed. RESULTS: In men, IGF-I was 21.7 +/- 2.6% lower in Afro-Caribbeans than white Europeans (P < 0.0001) but there were no differences between other ethnic groups. In women, IGF-I was 14.2 +/- 5.1% lower in Afro-Caribbeans (P = 0.005) and 15.6 +/- 7.0% higher in Orientals (P = 0.02) compared with white Europeans. P-III-P was 15.2 +/- 3.5%, 26.6 +/- 6.6% and 19.3 +/- 5.8% lower in Afro-Caribbean (P < 0.0001), Indo-Asian (P < 0.0001) and Oriental men (P = 0.001), respectively, compared with white European men. In women, P-III-P was 15.7 +/- 4.7% lower in Afro-Caribbeans compared to white Europeans (P =0.0009) but there were no differences between other ethnicities. Despite these differences, most observations were below the upper 99% prediction limits derived from white European athletes. All GH-2000 scores lay below the cut-off limit proposed for doping. CONCLUSIONS: The GH-2000 detection method based on IGF-I and P-III-P would be valid in all ethnic groups
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Published date: January 2009
Keywords:
women, metabolism, prediction, disease, procollagen, ethnic groups, developmental origins, health, endocrinology
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Local EPrints ID: 70379
URI: http://eprints.soton.ac.uk/id/eprint/70379
PURE UUID: 1b920a71-9229-4805-be7a-fa96784aba63
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Date deposited: 02 Feb 2010
Last modified: 14 Mar 2024 02:45
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Contributors
Author:
Ioulietta Erotokritou-Mulligan
Author:
E. Eryl Bassett
Author:
David A. Cowan
Author:
Christiaan Bartlett
Author:
Cathy McHugh
Author:
Peter H. Sonksen
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