Epidemiology of osteoporosis
Epidemiology of osteoporosis
Osteoporosis is a skeletal disorder characterized by low bone mass and micro-architectural deterioration of bone tissue with a consequent increase in the fragility of bone and hence susceptibility to fracture.1 Historically, the term ‘osteoporosis’ first entered medial terminology in France and Germany in the nineteenth century, as a descriptive term emphasizing the porosity of the histological appearances of aged human bone. Prior to this, however, work published by Sir Astley Cooper suggested that certain types of fracture may occur due to age-related reduction in bone mass or quality.2 He described the original classical epidemiological hallmarks of these fractures: incidence rates that increase with age; rates which are higher among women than men; and fractures which are associated with only moderate trauma at sites containing large amounts of trabecular bone. These features are typified by fractures of the proximal femur, distal radius and vertebra, but fractures at other sites – such as the pelvis, proximal humerus, and proximal tibia – show similar patterns. These fractures are the serious and important outcomes of the condition and lead to severe mortality and morbidity, a significant burden on society in general, and a huge economic impact.3 Osteoporotic fractures alone cost the United States around $17.9 billion per annum, and the United Kingdom around £1.7 billion (Table 1).4
Table 1.
fracture, health, humans, metabolism, male, mortality, public health, female, bone mass, bone, life, epidemiology, fractures, osteoporosis, accidental falls, hip, bone density, review, development, disease, risk, mass, association
671-685
Holroyd, Christopher
54c0e4c6-290f-4e5e-b966-4f316d656a02
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Dennison, Elaine
d807ff08-222c-4079-99f1-05c33611be9b
October 2008
Holroyd, Christopher
54c0e4c6-290f-4e5e-b966-4f316d656a02
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Dennison, Elaine
d807ff08-222c-4079-99f1-05c33611be9b
Holroyd, Christopher, Cooper, Cyrus and Dennison, Elaine
(2008)
Epidemiology of osteoporosis.
Best Practice & Research Clinical Endocrinology & Metabolism, 22 (5), .
(doi:10.1016/j.beem.2008.06.001).
Abstract
Osteoporosis is a skeletal disorder characterized by low bone mass and micro-architectural deterioration of bone tissue with a consequent increase in the fragility of bone and hence susceptibility to fracture.1 Historically, the term ‘osteoporosis’ first entered medial terminology in France and Germany in the nineteenth century, as a descriptive term emphasizing the porosity of the histological appearances of aged human bone. Prior to this, however, work published by Sir Astley Cooper suggested that certain types of fracture may occur due to age-related reduction in bone mass or quality.2 He described the original classical epidemiological hallmarks of these fractures: incidence rates that increase with age; rates which are higher among women than men; and fractures which are associated with only moderate trauma at sites containing large amounts of trabecular bone. These features are typified by fractures of the proximal femur, distal radius and vertebra, but fractures at other sites – such as the pelvis, proximal humerus, and proximal tibia – show similar patterns. These fractures are the serious and important outcomes of the condition and lead to severe mortality and morbidity, a significant burden on society in general, and a huge economic impact.3 Osteoporotic fractures alone cost the United States around $17.9 billion per annum, and the United Kingdom around £1.7 billion (Table 1).4
Table 1.
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Published date: October 2008
Keywords:
fracture, health, humans, metabolism, male, mortality, public health, female, bone mass, bone, life, epidemiology, fractures, osteoporosis, accidental falls, hip, bone density, review, development, disease, risk, mass, association
Identifiers
Local EPrints ID: 70417
URI: http://eprints.soton.ac.uk/id/eprint/70417
ISSN: 1521-690X
PURE UUID: 6506d21a-43da-47ca-b0c0-c423a14cfa98
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Date deposited: 09 Mar 2010
Last modified: 18 Mar 2024 02:44
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Author:
Christopher Holroyd
Author:
Elaine Dennison
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