Serum profiling reveals distinctive proteomic markers in the serum from chronic myeloid leukaemia patients
Serum profiling reveals distinctive proteomic markers in the serum from chronic myeloid leukaemia patients
We have shown that proteomic profiling of sera from chronic myeloid leukaemia patients at presentation identifies five serum markers whose expression profile is significantly different from that seen in normal controls, non-malignant neutrophilia and in CML patients in HR following treatment with Gleevec. Of particular interest is the persistence of three of the five biomarkers following successful induction of HR, suggesting that those changes are disease specific. We have demonstrated that serum profiling can robustly identify disease groups and disease state in patients with CML compared with non-malignant and normal controls. In addition our data suggest that serum profiling of other haematological malignancies may provide new biomarkers for disease state and stage
chronic myeloid leukaemia, serum profiling, biomarkers, SELDI-TOF mass spectrometry, proteomics
263-265
Mohamedali, Azim
bf5195ae-fe4f-43d7-9dc5-222d2e5776d3
Guinn, Barbara-ann
728d28c9-a23d-413a-ba1d-4531005705d7
Sahu, Satyajit
7fc4ad84-492f-4aa4-bf79-1c05350f4719
Thomas, N.S.
df2d7c6d-2c96-4aaa-a7ef-7f7987759cf4
Mufti, Ghulam J.
940de420-bc41-4006-8517-f2c926ba70aa
January 2009
Mohamedali, Azim
bf5195ae-fe4f-43d7-9dc5-222d2e5776d3
Guinn, Barbara-ann
728d28c9-a23d-413a-ba1d-4531005705d7
Sahu, Satyajit
7fc4ad84-492f-4aa4-bf79-1c05350f4719
Thomas, N.S.
df2d7c6d-2c96-4aaa-a7ef-7f7987759cf4
Mufti, Ghulam J.
940de420-bc41-4006-8517-f2c926ba70aa
Mohamedali, Azim, Guinn, Barbara-ann, Sahu, Satyajit, Thomas, N.S. and Mufti, Ghulam J.
(2009)
Serum profiling reveals distinctive proteomic markers in the serum from chronic myeloid leukaemia patients.
British Journal of Haematology, 144 (2), .
(doi:10.1111/j.1365-2141.2008.07434.x).
Abstract
We have shown that proteomic profiling of sera from chronic myeloid leukaemia patients at presentation identifies five serum markers whose expression profile is significantly different from that seen in normal controls, non-malignant neutrophilia and in CML patients in HR following treatment with Gleevec. Of particular interest is the persistence of three of the five biomarkers following successful induction of HR, suggesting that those changes are disease specific. We have demonstrated that serum profiling can robustly identify disease groups and disease state in patients with CML compared with non-malignant and normal controls. In addition our data suggest that serum profiling of other haematological malignancies may provide new biomarkers for disease state and stage
This record has no associated files available for download.
More information
Published date: January 2009
Keywords:
chronic myeloid leukaemia, serum profiling, biomarkers, SELDI-TOF mass spectrometry, proteomics
Identifiers
Local EPrints ID: 71030
URI: http://eprints.soton.ac.uk/id/eprint/71030
ISSN: 0007-1048
PURE UUID: bb580f7d-04cc-47e3-b8c4-1dd8e14f995b
Catalogue record
Date deposited: 14 Dec 2009
Last modified: 13 Mar 2024 20:17
Export record
Altmetrics
Contributors
Author:
Azim Mohamedali
Author:
Barbara-ann Guinn
Author:
Satyajit Sahu
Author:
N.S. Thomas
Author:
Ghulam J. Mufti
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics