Chronic surgical site infection due to suture-associated polymicrobial biofilm
Kathju, Sandeep, Nistico, Laura, Hall-Stoodley, Luanne, Post, J. Christopher, Ehrlich, Garth D. and Stoodley, Paul (2009) Chronic surgical site infection due to suture-associated polymicrobial biofilm. Surgical Infections, 10, (5), 457-461. (doi:10.1089/sur.2008.062).
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Background: surgical site infection (SSI) is a common surgical complication; culture-negative SSI presents a particular problem in management.
Methods: examination of explanted foreign bodies (sutures) using confocal laser scanning microscopy (CLSM) and fluorescent in situ hybridization (FISH) after surgical exploration of a chronic culture-negative SSI.
Results: confocal microscopy (CM) demonstrated bacilli and cocci attached to the surface of the explanted sutures in a mixed biofilm. Florescent in situ hybridization confirmed that Staphylococci were components of the mixed biofilm. Removal of the foreign bodies (sutures) resolved the chronic infection.
Conclusion: chronic SSI can arise from underlying bacterial biofilms, which can invest implanted foreign bodies and associated soft tissue surfaces
|Digital Object Identifier (DOI):||doi:10.1089/sur.2008.062|
|Additional Information:||The National Centre for Advanced Tribology at Southampton (nCATS)|
|Subjects:||R Medicine > RD Surgery
Q Science > QH Natural history > QH301 Biology
|Divisions:||University Structure - Pre August 2011 > School of Engineering Sciences
|Date Deposited:||18 Dec 2009|
|Last Modified:||31 Mar 2016 13:03|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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