Chronic surgical site infection due to suture-associated polymicrobial biofilm
Kathju, Sandeep, Nistico, Laura, Hall-Stoodley, Luanne, Post, J. Christopher, Ehrlich, Garth D. and Stoodley, Paul (2009) Chronic surgical site infection due to suture-associated polymicrobial biofilm. Surgical Infections, 10, (5), 457-461. (doi:10.1089/sur.2008.062).
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Description/Abstract
Background: surgical site infection (SSI) is a common surgical complication; culture-negative SSI presents a particular problem in management.
Methods: examination of explanted foreign bodies (sutures) using confocal laser scanning microscopy (CLSM) and fluorescent in situ hybridization (FISH) after surgical exploration of a chronic culture-negative SSI.
Results: confocal microscopy (CM) demonstrated bacilli and cocci attached to the surface of the explanted sutures in a mixed biofilm. Florescent in situ hybridization confirmed that Staphylococci were components of the mixed biofilm. Removal of the foreign bodies (sutures) resolved the chronic infection.
Conclusion: chronic SSI can arise from underlying bacterial biofilms, which can invest implanted foreign bodies and associated soft tissue surfaces
| Item Type: | Article |
|---|---|
| Additional Information: | The National Centre for Advanced Tribology at Southampton (nCATS) |
| ISSNs: | 1096-2964 (print) |
| Related URLs: | |
| Subjects: | R Medicine > RD Surgery Q Science > QH Natural history > QH301 Biology |
| Divisions: | University Structure - Pre August 2011 > School of Engineering Sciences |
| Item ID: | 71638 |
| Date Deposited: | 18 Dec 2009 |
| Last Modified: | 23 Jul 2012 00:29 |
| Contributors: | Kathju, Sandeep (Author) Nistico, Laura (Author) Hall-Stoodley, Luanne (Author) Post, J. Christopher (Author) Ehrlich, Garth D. (Author) Stoodley, Paul (Author) |
| Date: | November 2009 |
| Additional Information: | The National Centre for Advanced Tribology at Southampton (nCATS) |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/71638 |
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