Chronic surgical site infection due to suture-associated polymicrobial biofilm


Kathju, Sandeep, Nistico, Laura, Hall-Stoodley, Luanne, Post, J. Christopher, Ehrlich, Garth D. and Stoodley, Paul (2009) Chronic surgical site infection due to suture-associated polymicrobial biofilm. Surgical Infections, 10, (5), 457-461. (doi:10.1089/sur.2008.062).

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Original Publication URL: http://dx.doi.org/10.1089/sur.2008.062

Description/Abstract

Background: surgical site infection (SSI) is a common surgical complication; culture-negative SSI presents a particular problem in management.

Methods: examination of explanted foreign bodies (sutures) using confocal laser scanning microscopy (CLSM) and fluorescent in situ hybridization (FISH) after surgical exploration of a chronic culture-negative SSI.

Results: confocal microscopy (CM) demonstrated bacilli and cocci attached to the surface of the explanted sutures in a mixed biofilm. Florescent in situ hybridization confirmed that Staphylococci were components of the mixed biofilm. Removal of the foreign bodies (sutures) resolved the chronic infection.

Conclusion: chronic SSI can arise from underlying bacterial biofilms, which can invest implanted foreign bodies and associated soft tissue surfaces

Item Type: Article
Additional Information: The National Centre for Advanced Tribology at Southampton (nCATS)
ISSNs: 1096-2964 (print)
Related URLs:
Subjects: R Medicine > RD Surgery
Q Science > QH Natural history > QH301 Biology
Divisions: University Structure - Pre August 2011 > School of Engineering Sciences
ePrint ID: 71638
Date Deposited: 18 Dec 2009
Last Modified: 27 Mar 2014 18:51
URI: http://eprints.soton.ac.uk/id/eprint/71638

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