Early detection of osteoarthritis and articular cartilage aging in mice and patient biopsies using atomic force microscopy

Stolz, Martin, Gottardi, Riccardo, Raiteri, Roberto, Miot, Sylvie, Martin, Ivan, Imer, Raphael, Staufer, Urs, Raducanu, Aurelia, Duggelin, Marcel, Baschong, Werner, Daniels, A.U., Friederich, Niklaus F., Aszodi, Attila and Aebi, Ueli (2009) Early detection of osteoarthritis and articular cartilage aging in mice and patient biopsies using atomic force microscopy. Nature Nanotechnology, 4, 186-192. (doi:10.1038/nnano.2008.410).


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Original Publication URL: http://dx.doi.org/10.1038/nnano.2008.410


The pathological changes in osteoarthritis—a degenerative joint disease prevalent among older people—start at the molecular scale and spread to the higher levels of the architecture of articular cartilage to cause progressive and irreversible structural and functional damage. At present, there are no treatments to cure or attenuate the degradation of cartilage. Early detection and the ability to monitor the progression of osteoarthritis are therefore important for developing effective therapies. Here, we show that indentation-type atomic force microscopy can monitor age-related morphological and biomechanical changes in the hips of normal and osteoarthritic mice. Early damage in the cartilage of osteoarthritic patients undergoing hip or knee replacements could similarly be detected using this method. Changes due to aging and osteoarthritis are clearly depicted at the nanometre scale well before morphological changes can be observed using current diagnostic methods. Indentation-type atomic force microscopy may potentially be developed into a minimally invasive arthroscopic tool to diagnose the early onset of osteoarthritis in situ

Item Type: Article
Digital Object Identifier (DOI): doi:10.1038/nnano.2008.410
Additional Information: The National Centre for Advanced Tribology at Southampton (nCATS)
ISSNs: 1748-3387 (print)
Related URLs:
Subjects: Q Science > Q Science (General)
R Medicine > R Medicine (General)
Divisions : University Structure - Pre August 2011 > School of Engineering Sciences
ePrint ID: 71689
Accepted Date and Publication Date:
March 2009Published
Date Deposited: 23 Dec 2009
Last Modified: 31 Mar 2016 13:03
URI: http://eprints.soton.ac.uk/id/eprint/71689

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