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Myopia and polmorphisms in genes for matrix metalloproteinases

Myopia and polmorphisms in genes for matrix metalloproteinases
Myopia and polmorphisms in genes for matrix metalloproteinases
PURPOSE. To investigate the relation between myopia and variations in three genes coding for matrix metalloproteinases, enzymes that degrade matrix proteins and modulate scleral extensibility.
METHODS. Three hundred sixty-six men and women, from Sheffield, United Kingdom, were genotyped for the 1G/2G polymorphism in the MMP-1 gene, the 5A/6A polymorphism in the MMP-3 gene and the ArgGln polymorphism in exon 6 of the MMP-9 gene and assessed for refractive error.
RESULTS. Risk of myopia was increased in people homozygous for the 5A allele of the MMP-3 gene (odds ratio [OR], 3.1; 95% confidence interval [CI], 1.1–9.0) compared to those who were homozygous for the 6A allele, and in people homozygous for the Gln allele in exon 6 of the MMP-9 gene (OR, 2.8; 95% CI, 1.1–7.0) compared to those who were homozygous for the Arg allele. People who were homozygous for the 2G allele of the MMP-1 gene had an odds ratio for myopia of 2.3 (95% CI, 0.9–6.1), compared with those who were homozygous for the 1G allele, although this relation did not reach statistical significance. Risk of myopia increased progressively with the dose of these three alleles, showing a greater than 10-fold difference across the range.
0146-0404
2632-2636
Hall, Nigel F.
cd32d48e-a60b-4a7e-b1a2-99cfb8c68c58
Gale, Catharine R.
5bb2abb3-7b53-42d6-8aa7-817e193140c8
Ye, Shu
132b6474-1927-4f93-80db-2c620a31c1ab
Martyn, Christopher N.
eb9a7811-3550-4586-9aca-795f2ad05090
Hall, Nigel F.
cd32d48e-a60b-4a7e-b1a2-99cfb8c68c58
Gale, Catharine R.
5bb2abb3-7b53-42d6-8aa7-817e193140c8
Ye, Shu
132b6474-1927-4f93-80db-2c620a31c1ab
Martyn, Christopher N.
eb9a7811-3550-4586-9aca-795f2ad05090

Hall, Nigel F., Gale, Catharine R., Ye, Shu and Martyn, Christopher N. (2009) Myopia and polmorphisms in genes for matrix metalloproteinases. Investigative Ophthalmology & Visual Science, 50 (6), 2632-2636. (doi:10.1167/iovs.08-2427).

Record type: Article

Abstract

PURPOSE. To investigate the relation between myopia and variations in three genes coding for matrix metalloproteinases, enzymes that degrade matrix proteins and modulate scleral extensibility.
METHODS. Three hundred sixty-six men and women, from Sheffield, United Kingdom, were genotyped for the 1G/2G polymorphism in the MMP-1 gene, the 5A/6A polymorphism in the MMP-3 gene and the ArgGln polymorphism in exon 6 of the MMP-9 gene and assessed for refractive error.
RESULTS. Risk of myopia was increased in people homozygous for the 5A allele of the MMP-3 gene (odds ratio [OR], 3.1; 95% confidence interval [CI], 1.1–9.0) compared to those who were homozygous for the 6A allele, and in people homozygous for the Gln allele in exon 6 of the MMP-9 gene (OR, 2.8; 95% CI, 1.1–7.0) compared to those who were homozygous for the Arg allele. People who were homozygous for the 2G allele of the MMP-1 gene had an odds ratio for myopia of 2.3 (95% CI, 0.9–6.1), compared with those who were homozygous for the 1G allele, although this relation did not reach statistical significance. Risk of myopia increased progressively with the dose of these three alleles, showing a greater than 10-fold difference across the range.

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More information

Published date: 11 March 2009
Organisations: Dev Origins of Health & Disease

Identifiers

Local EPrints ID: 71694
URI: http://eprints.soton.ac.uk/id/eprint/71694
ISSN: 0146-0404
PURE UUID: e96557df-ca47-44b5-9e80-22d75c8fbe61
ORCID for Catharine R. Gale: ORCID iD orcid.org/0000-0002-3361-8638

Catalogue record

Date deposited: 18 Dec 2009
Last modified: 14 Mar 2024 02:38

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Contributors

Author: Nigel F. Hall
Author: Shu Ye
Author: Christopher N. Martyn

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