Hyporesponsive reward anticipation in the basal ganglia following severe institutional deprivation early in life
Hyporesponsive reward anticipation in the basal ganglia following severe institutional deprivation early in life
Severe deprivation in the first few years of life is associated with multiple difficulties in cognition and behavior. However, the brain basis for these difficulties is poorly understood. Structural and functional neuroimaging studies have implicated limbic system structures as dysfunctional, and one functional imaging study in a heterogeneous group of maltreated individuals has confirmed the presence of abnormalities in the basal ganglia. Based on these studies and known dopaminergic abnormalities from studies in experimental animals using social isolation, we used a task of monetary reward anticipation to examine the functional integrity of brain regions previously shown to be implicated in reward processing. Our sample included a group of adolescents (n = 12) who had experienced global deprivation early in their lives in Romania prior to adoption into UK families. In contrast to a nonadopted comparison group (n = 11), the adoptees did not recruit the striatum during reward anticipation despite comparable performance accuracy and latency. These results show, for the first time, an association between early institutional deprivation and brain reward systems in humans and highlight potential neural vulnerabilities resulting from such exposures
2316-2325
Mehta, Mitul A.
656d4095-c3a0-4161-8cb7-0dafcaf1404e
Gore-Langton, Emma
c4eca560-12b9-4a70-9402-03da771f1cf9
Golembo, Nicole
fcd91412-54ba-42be-82c7-800a2fc6f8c7
Colvert, Emma
667ed4c9-d3de-45cf-b173-b446b6e18eed
Williams, Steven C.R.
83da08dc-0034-4f0e-ae2c-d05dee0731ba
Sonuga-Barke, Edmund
bc80bf95-6cf9-4c76-a09d-eaaf0b717635
2009
Mehta, Mitul A.
656d4095-c3a0-4161-8cb7-0dafcaf1404e
Gore-Langton, Emma
c4eca560-12b9-4a70-9402-03da771f1cf9
Golembo, Nicole
fcd91412-54ba-42be-82c7-800a2fc6f8c7
Colvert, Emma
667ed4c9-d3de-45cf-b173-b446b6e18eed
Williams, Steven C.R.
83da08dc-0034-4f0e-ae2c-d05dee0731ba
Sonuga-Barke, Edmund
bc80bf95-6cf9-4c76-a09d-eaaf0b717635
Mehta, Mitul A., Gore-Langton, Emma, Golembo, Nicole, Colvert, Emma, Williams, Steven C.R. and Sonuga-Barke, Edmund
(2009)
Hyporesponsive reward anticipation in the basal ganglia following severe institutional deprivation early in life.
Journal of Cognitive Neuroscience, 22 (10), .
(doi:10.1162/jocn.2009.21394).
Abstract
Severe deprivation in the first few years of life is associated with multiple difficulties in cognition and behavior. However, the brain basis for these difficulties is poorly understood. Structural and functional neuroimaging studies have implicated limbic system structures as dysfunctional, and one functional imaging study in a heterogeneous group of maltreated individuals has confirmed the presence of abnormalities in the basal ganglia. Based on these studies and known dopaminergic abnormalities from studies in experimental animals using social isolation, we used a task of monetary reward anticipation to examine the functional integrity of brain regions previously shown to be implicated in reward processing. Our sample included a group of adolescents (n = 12) who had experienced global deprivation early in their lives in Romania prior to adoption into UK families. In contrast to a nonadopted comparison group (n = 11), the adoptees did not recruit the striatum during reward anticipation despite comparable performance accuracy and latency. These results show, for the first time, an association between early institutional deprivation and brain reward systems in humans and highlight potential neural vulnerabilities resulting from such exposures
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Published date: 2009
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Local EPrints ID: 71866
URI: http://eprints.soton.ac.uk/id/eprint/71866
ISSN: 0898-929X
PURE UUID: 60d1bf4c-5747-4fc1-8739-6e0ed038074a
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Date deposited: 07 Jan 2010
Last modified: 13 Mar 2024 20:48
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Contributors
Author:
Mitul A. Mehta
Author:
Emma Gore-Langton
Author:
Nicole Golembo
Author:
Emma Colvert
Author:
Steven C.R. Williams
Author:
Edmund Sonuga-Barke
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