Low maternal vitamin D status and fetal bone development: cohort study
Mahon, Pamela, Harvey, Nicholas, Crozier, Sarah, Inskip, Hazel, Robinson, Sian, Arden, Nigel, Swaminathan, Rama, Cooper, Cyrus and Godfrey, Keith (2010) Low maternal vitamin D status and fetal bone development: cohort study. Journal of Bone and Mineral Research, 25, (1), 14-19. (doi:10.1359/jbmr.090701).
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Description/Abstract
Recent findings suggest that maternal vitamin D insufficiency during pregnancy has consequences for the offspring's bone health in later life. To investigate whether maternal vitamin D insufficiency affects fetal femur growth in ways similar to those seen in childhood rickets and study the timing during gestation of any effect of maternal vitamin D status, we studied 424 pregnant women within a prospective longitudinal study of maternal nutrition and lifestyle before and during pregnancy (Southampton Women's Survey). Using high-resolution 3D ultrasound, we measured fetal femur length and distal metaphyseal cross-sectional area, together with the ratio of femoral metaphyseal cross-sectional area to femur length (femoral splaying index). Lower maternal 25-hydroxyvitamin vitamin D concentration was not related to fetal femur length but was associated with greater femoral metaphyseal cross-sectional area and a higher femoral splaying index at 19 weeks' gestation [r = -0.16, 95% confidence interbal (CI) -0.25 to -0.06 and r = -0.17, 95% CI -0.26 to -0.07, respectively] and at 34 weeks' gestation (r = -0.10, 95% CI -0.20 to 0.00 and r = -0.11, 95% CI -0.21 to -0.01, respectively). Three groups of women were identified with 25-hydroxyvitamin vitamin D concentrations that were sufficient/borderline (>50 nmol/L, 63.4%), insufficient (25 to 50 nmol/L, 30.7%), and deficient (25 nmol/L, 5.9%). Across these groups, the geometric mean femoral splaying indices at 19 weeks' gestation increased from 0.074 (sufficient/borderline) to 0.078 (insufficient) and 0.084 (deficient). Our observations suggest that maternal vitamin D insufficiency can influence fetal femoral development as early as 19 weeks' gestation. This suggests that measures to improve maternal vitamin D status should be instituted in early pregnancy
| Item Type: | Article |
|---|---|
| ISSNs: | 0884-0431 (print) |
| Related URLs: | |
| Keywords: | vitamin D, fetus, developmental origins, osteoporosis, three-dimensional ultrasound |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease |
| Item ID: | 72534 |
| Date Deposited: | 17 Feb 2010 |
| Last Modified: | 23 Jul 2012 23:19 |
| Contributors: | Mahon, Pamela (Author) Harvey, Nicholas (Author) Crozier, Sarah (Author) Inskip, Hazel (Author) Robinson, Sian (Author) Arden, Nigel (Author) Swaminathan, Rama (Author) Cooper, Cyrus (Author) Godfrey, Keith (Author) |
| Date: | January 2010 |
| Status: | Published |
| Contact Email Address: | kmg@mrc.soton.ac.uk |
| URI: | http://eprints.soton.ac.uk/id/eprint/72534 |
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