Unexpectedly high incidence of indigenous acute hepatitis E within South Hampshire: time for routine testing?
De Silva, Aminda N., Muddu, Ajay K., Iredale, John P., Sheron, Nick, Khakoo, Salim I. and Pelosii, Emanuela (2007) Unexpectedly high incidence of indigenous acute hepatitis E within South Hampshire: time for routine testing? Journal of Medical Virology, 80, (2), 283-288. (doi:10.1002/jmv.21062).
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Description/Abstract
Hepatitis E indigenous to developed countries (hepatitis EIDC) is a form of hepatitis E in persons with no travel history to highly endemic areas. It has been recognized recently as an emerging clinical entity in a significant number of economically developed countries including UK. However, it is still perceived as a rare disease and routine laboratory testing for hepatitis E is not performed. A series of 13 cases of hepatitis EIDC, diagnosed in a 13-month period from June 2005 within a single center in South Hampshire, UK, is presented. These patients were identified after implementing a novel-screening algorithm that introduced routine hepatitis E serological investigations. Patients were middle aged or elderly and males were affected more commonly. Four patients (31%) required hospital admission. All reverse transcriptase-polymerase chain reaction (RT-PCR) confirmed cases carried hepatitis E virus (HEV) genotype-3, which bore close sequence homology to HEV circulating in UK pigs. None of these patients recalled eating undercooked pork products or close contact with pigs during the 2 months preceding the onset of acute hepatitis. In comparison, during the same period, only two cases of hepatitis A and five cases of acute hepatitis B were diagnosed. These data illustrate the importance of introducing routine hepatitis E testing in all patients with unexplained acute liver disease and absence of relevant travel history. Routine testing can clarify hepatitis E epidemiology whilst improving the clinical management of patients with acute liver disease.
| Item Type: | Article |
|---|---|
| ISSNs: | 0146-6615 (print) |
| Related URLs: | |
| Subjects: | R Medicine > R Medicine (General) Q Science > QR Microbiology > QR355 Virology |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Infection, Inflammation and Repair |
| Item ID: | 72593 |
| Date Deposited: | 18 Feb 2010 |
| Last Modified: | 01 Jun 2011 03:00 |
| Contributors: | De Silva, Aminda N. (Author) Muddu, Ajay K. (Author) Iredale, John P. (Author) Sheron, Nick (Author) Khakoo, Salim I. (Author) Pelosii, Emanuela (Author) |
| Date: | December 2007 |
| Status: | Published |
| Contact Email Address: | emanuela.pelosi@suht.swest.nhs.uk |
| URI: | http://eprints.soton.ac.uk/id/eprint/72593 |
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