Unexpectedly high incidence of indigenous acute hepatitis E within South Hampshire: time for routine testing?

De Silva, Aminda N., Muddu, Ajay K., Iredale, John P., Sheron, Nick, Khakoo, Salim I. and Pelosii, Emanuela (2007) Unexpectedly high incidence of indigenous acute hepatitis E within South Hampshire: time for routine testing? Journal of Medical Virology, 80, (2), 283-288. (doi:10.1002/jmv.21062).


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Original Publication URL: http://dx.doi.org/10.1002/jmv.21062


Hepatitis E indigenous to developed countries (hepatitis EIDC) is a form of hepatitis E in persons with no travel history to highly endemic areas. It has been recognized recently as an emerging clinical entity in a significant number of economically developed countries including UK. However, it is still perceived as a rare disease and routine laboratory testing for hepatitis E is not performed. A series of 13 cases of hepatitis EIDC, diagnosed in a 13-month period from June 2005 within a single center in South Hampshire, UK, is presented. These patients were identified after implementing a novel-screening algorithm that introduced routine hepatitis E serological investigations. Patients were middle aged or elderly and males were affected more commonly. Four patients (31%) required hospital admission. All reverse transcriptase-polymerase chain reaction (RT-PCR) confirmed cases carried hepatitis E virus (HEV) genotype-3, which bore close sequence homology to HEV circulating in UK pigs. None of these patients recalled eating undercooked pork products or close contact with pigs during the 2 months preceding the onset of acute hepatitis. In comparison, during the same period, only two cases of hepatitis A and five cases of acute hepatitis B were diagnosed. These data illustrate the importance of introducing routine hepatitis E testing in all patients with unexplained acute liver disease and absence of relevant travel history. Routine testing can clarify hepatitis E epidemiology whilst improving the clinical management of patients with acute liver disease.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1002/jmv.21062
ISSNs: 0146-6615 (print)
Related URLs:
Subjects: R Medicine > R Medicine (General)
Q Science > QR Microbiology > QR355 Virology
Divisions : University Structure - Pre August 2011 > School of Medicine > Infection, Inflammation and Repair
ePrint ID: 72593
Accepted Date and Publication Date:
December 2007Published
Date Deposited: 18 Feb 2010
Last Modified: 31 Mar 2016 13:04
URI: http://eprints.soton.ac.uk/id/eprint/72593

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