Letter. Variant IRF4|[sol]|MUM1 associates with CD38 status and treatment-free survival in chronic lymphocytic leukaemia
Allan, J.M., Bailey, J.R., Pettitt, A.R., Harris, R.J., Pepper, C., Fegan, C., Strefford, J.C., Oscier, D.G., Pratt, G. and Allsup, D.J. (2010) Letter. Variant IRF4|[sol]|MUM1 associates with CD38 status and treatment-free survival in chronic lymphocytic leukaemia. Leukemia (doi:10.1038/leu.2009.298).
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A low penetrance risk allele (defined by rs872071) for chronic lymphocytic leukaemia (CLL) has been identified at the interferon regulatory factor 4 (IRF4)|[sol]|multiple myeloma oncogene (MUM1) locus at 6p25.3.1 Given a putative role for IRF4 in the aetiology of CLL and a role in regulating B-cell development, we hypothesised that genetic variation in this gene also has a role in determining prognosis in CLL.
|Subjects:||R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)|
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Cancer Sciences
|Date Deposited:||02 Mar 2010|
|Last Modified:||02 Mar 2012 12:14|
|Contributors:||Allan, J.M. (Author)
Bailey, J.R. (Author)
Pettitt, A.R. (Author)
Harris, R.J. (Author)
Pepper, C. (Author)
Fegan, C. (Author)
Strefford, J.C. (Author)
Oscier, D.G. (Author)
Pratt, G. (Author)
Allsup, D.J. (Author)
|Date:||21 January 2010|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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