Interleukin-1 cytokines, inflammasomes, NOD-signalosomes and autoinflammation
Interleukin-1 cytokines, inflammasomes, NOD-signalosomes and autoinflammation
The understanding of the genetic and immunological basis of human periodic fever syndromes, in particular cryopyrin-associated periodic syndromes (CAPS), has led to important new insights into the pathogenesis of monogenic and complex interleukin-1beta-associated autoinflammatory diseases. Currently the focus of attention is on the nucleotide-binding oligomerization domain (NOD)-like receptors (NLR), which take part in the regulation of the synthesis and maturation of cytokines in the IL-1 families, NOD-signalosomes and inflammasomes
interleukin-1 cytokines, inflammasomes, nod-signalosomes, autoinflammation, hereditary autoinflammatory syndromes
712-719
Gadola, S.D.
ef2fa6cf-2ccc-4fea-a7a5-cc03a9d13ab1
November 2009
Gadola, S.D.
ef2fa6cf-2ccc-4fea-a7a5-cc03a9d13ab1
Gadola, S.D.
(2009)
Interleukin-1 cytokines, inflammasomes, NOD-signalosomes and autoinflammation.
Zeitschrift für Rheumatologie, 68 (9), .
(doi:10.1007/s00393-009-0488-5).
Abstract
The understanding of the genetic and immunological basis of human periodic fever syndromes, in particular cryopyrin-associated periodic syndromes (CAPS), has led to important new insights into the pathogenesis of monogenic and complex interleukin-1beta-associated autoinflammatory diseases. Currently the focus of attention is on the nucleotide-binding oligomerization domain (NOD)-like receptors (NLR), which take part in the regulation of the synthesis and maturation of cytokines in the IL-1 families, NOD-signalosomes and inflammasomes
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Published date: November 2009
Keywords:
interleukin-1 cytokines, inflammasomes, nod-signalosomes, autoinflammation, hereditary autoinflammatory syndromes
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Local EPrints ID: 72706
URI: http://eprints.soton.ac.uk/id/eprint/72706
ISSN: 0340-1855
PURE UUID: 6e1825aa-fed1-4ad4-bba6-eb483930a59f
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Date deposited: 19 Feb 2010
Last modified: 13 Mar 2024 21:39
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Author:
S.D. Gadola
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