Noninvasive fetal electrocardiography following intermittent umbilical cord occlusion in the preterm ovine fetus
Cleal, J.K., Thomas, M., Hanson, M.A., Paterson-Brown, S., Gardiner, H.M. and Green, L.R. (2010) Noninvasive fetal electrocardiography following intermittent umbilical cord occlusion in the preterm ovine fetus. BJOG: British Journal of Obstetrics and Gynaecology, 117, (4), 438-444. (doi:10.1111/j.1471-0528.2009.02471.x).
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Objective: to investigate whether a noninvasive fetal electrocardiography (fECG) system can identify cardiovascular responses to fetal hypoxaemia and validate the results using standard invasive fECG monitoring techniques.
Design: prospective cohort study.
Setting: biological research facilities at The University of Southampton.
Population or Sample: late gestation ovine fetuses; n = 5.
Methods: five fetal lambs underwent implantation of vascular catheters, umbilical cord occluder and invasive ECG chest electrodes under general anaesthesia (3% halothane/O2) at 119 days of gestation (term ∼147 days of gestation). After 5 days of recovery blood pressure, blood gases, glucose and pH were monitored. At 124 and 125 days of gestation following a 10-minute baseline period a 90-second cord occlusion was applied. Noninvasive fetal ECG was recorded from maternal transabdominal electrodes using advanced signal-processing techniques, concurrently with invasive fECG recordings.
Main outcome measures: comparison of T:QRS ratios of the ECG waveform from noninvasive and invasive fECG monitoring systems.
Results: our fECG monitoring system is able to demonstrate changes in waveforms during periods of hypoxaemia similar to those obtained invasively, which could indicate fetal distress.
Conclusions: these findings may indicate a future use for noninvasive electrocardiography during human fetal monitoring both before and during labour in term and preterm pregnancies
|Subjects:||R Medicine > RG Gynecology and obstetrics
Q Science > QP Physiology
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
|Date Deposited:||23 Feb 2010|
|Last Modified:||01 Jun 2011 15:10|
|Contributors:||Cleal, J.K. (Author)
Thomas, M. (Author)
Hanson, M.A. (Author)
Paterson-Brown, S. (Author)
Gardiner, H.M. (Author)
Green, L.R. (Author)
|Contact Email Address:||firstname.lastname@example.org|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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