Potential directions for drug development for osteoarthritis
Roach, Helmtrud I. (2008) Potential directions for drug development for osteoarthritis. Expert Opinion on Drug Discovery, 3, (5), 475-486. (doi:10.1517/17460418.104.22.1685).
- Accepted Manuscript
Background: osteoarthritis (OA) is a frustrating disease for both patient and physician because neither cause nor cure is known and there are currently no disease-modifying drugs. Objective: To review current therapeutic approaches as well as new findings regarding OA pathoetiology that could form the basis of future direction for the development of drugs to prevent or slow down disease progression. Methods: After reviewing disease progression in human OA, as demonstrated by histological analyses, the reasons for cartilage erosion are explored and possible therapeutic approaches are highlighted. Results/conclusions: OA may be an epigenetic disease. This new concept can explain many aspects of the disease and provide reasons why therapeutic approaches until now have met with little success.
|Digital Object Identifier (DOI):||doi:10.1517/17460422.214.171.1245|
|Additional Information:||Invited review|
|Keywords:||aggrecanases, articular chondrocyte, DNA methylation, drug development, epigenetics, matrix metalloproteases, osteoarthritis, pathoetiology|
|Subjects:||R Medicine > R Medicine (General)
R Medicine > RZ Other systems of medicine
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
|Date Deposited:||23 Feb 2010|
|Last Modified:||06 Aug 2015 02:57|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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