Potential directions for drug development for osteoarthritis

Roach, Helmtrud I. (2008) Potential directions for drug development for osteoarthritis. Expert Opinion on Drug Discovery, 3, (5), 475-486. (doi:10.1517/17460441.3.5.475).


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Original Publication URL: http://dx.doi.org/10.1517/17460441.3.5.475


Background: osteoarthritis (OA) is a frustrating disease for both patient and physician because neither cause nor cure is known and there are currently no disease-modifying drugs. Objective: To review current therapeutic approaches as well as new findings regarding OA pathoetiology that could form the basis of future direction for the development of drugs to prevent or slow down disease progression. Methods: After reviewing disease progression in human OA, as demonstrated by histological analyses, the reasons for cartilage erosion are explored and possible therapeutic approaches are highlighted. Results/conclusions: OA may be an epigenetic disease. This new concept can explain many aspects of the disease and provide reasons why therapeutic approaches until now have met with little success.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1517/17460441.3.5.475
Additional Information: Invited review
ISSNs: 1746-0441 (print)
Related URLs:
Keywords: aggrecanases, articular chondrocyte, DNA methylation, drug development, epigenetics, matrix metalloproteases, osteoarthritis, pathoetiology
Subjects: R Medicine > R Medicine (General)
R Medicine > RZ Other systems of medicine
Divisions : University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
ePrint ID: 72830
Accepted Date and Publication Date:
May 2008Published
Date Deposited: 23 Feb 2010
Last Modified: 31 Mar 2016 13:05
URI: http://eprints.soton.ac.uk/id/eprint/72830

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