Gp-340/DMBT1 in mucosal innate immunity
Madsen, J., Mollenhauer, J. and Holmskov, U. (2010) Gp-340/DMBT1 in mucosal innate immunity. Innate Immunity, 16, (3), 160-167. (PMID:PMID: 20418254). (In Press).
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Description/Abstract
Deleted in Malignant Brain Tumour 1 (DMBT1) is a gene that encodes alternatively spliced proteins involved in mucosal innate immunity. It also encodes a glycoprotein with a molecular mass of 340 kDa, and is referred to as gp-340 (DMBT1(gp340)) and salivary agglutinin (DMBT1(SAG)). DMBT1(gp340) is secreted into broncho-alveolar surface lining fluid whereas DMBT(SAG) is present in the saliva. The two molecules were shown to be identical and both interact with and agglutinate several Gram-negative and Gram-positive bacteria including Streptococcus mutans, a bacterium responsible for caries in the oral cavity. DMBT1(gp340) interacts with surfactant proteins A and D (SP-D). DMBT1(gp340) and SP-D can individually and together interact and agglutinate influenza A virus. DMBT1(gp340) also binds to HIV-1 and facilitates transcytosis of the virus into epithelial cells. DMBT1 binds to a variety of other host proteins, including serum and secretory IgA, C1q, lactoferrin, MUC5B and trefoil factor 2 (TFF2), all molecules with involvement in innate immunity and/or wound-healing processes. Recent generation of Dmbt1-deficient mice has provided the research field of DMBT1 with a model that allows research to progress from in vitro studies to in vivo functional studies of the multifunctional proteins encoded by the DMBT1 gene.
| Item Type: | Article |
|---|---|
| ISSNs: | 1753-4267 (print) |
| Related URLs: | |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Infection, Inflammation and Repair |
| Item ID: | 72851 |
| Date Deposited: | 24 Feb 2010 |
| Last Modified: | 23 Jul 2012 23:22 |
| Contributors: | Madsen, J. (Author) Mollenhauer, J. (Author) Holmskov, U. (Author) |
| Date: | 23 April 2010 |
| Status: | In Press |
| URI: | http://eprints.soton.ac.uk/id/eprint/72851 |
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