CD27 in defining memory B-cell origins in Waldenstrom’s macroglobulinemia
CD27 in defining memory B-cell origins in Waldenstrom’s macroglobulinemia
CD27 is a tumor necrosis factor receptor family glycoprotein, identified in seminal studies as an apparently robust marker for normal memory B cells. Somatic hypermutation (SHM) in immunoglobulin variable (V) region genes, however, remains the definitive memory imprint. In Waldenström's macroglobulinemia (WM), SHM defines a predominant mutated (MUT) subset and a minor unmutated subset indicative of naive B-cell origin. In MUT-WM, tumor cells can lack CD27 expression, raising suggestions of unusual memory B-cell origins. We recently identified such normal IgM+D+CD27-ve memory B-cells, with low levels of SHM in VH genes. While these could seed WM, the possibility remains that WM could derive from classical memory B cells that shed CD27. The utility of CD27 expression in defining memory in MUT-WM origins, then, is uncertain, but SHM unequivocally defines memory B-cell derivation in most WM. Patterns of SHM and additional IgH locus events furthermore reveal ongoing intra-tumoral diversification in WM
CD70, somatic hypermutation, v genes, waldenström
33-35
Sahota, Surinder S.
66c1457f-cba2-4c49-9c8c-fcee0748b6b8
Babbage, Gavin
d2036377-f36a-4a4a-8634-4b0394dffe28
Weston-Bell, Nicola J.
c99c8c28-519f-4c3e-bd8c-679995a0472e
March 2009
Sahota, Surinder S.
66c1457f-cba2-4c49-9c8c-fcee0748b6b8
Babbage, Gavin
d2036377-f36a-4a4a-8634-4b0394dffe28
Weston-Bell, Nicola J.
c99c8c28-519f-4c3e-bd8c-679995a0472e
Sahota, Surinder S., Babbage, Gavin and Weston-Bell, Nicola J.
(2009)
CD27 in defining memory B-cell origins in Waldenstrom’s macroglobulinemia.
Clinical Lymphoma and Myeloma, 9 (1), .
(doi:10.3816/CLM.2009.n.007).
Abstract
CD27 is a tumor necrosis factor receptor family glycoprotein, identified in seminal studies as an apparently robust marker for normal memory B cells. Somatic hypermutation (SHM) in immunoglobulin variable (V) region genes, however, remains the definitive memory imprint. In Waldenström's macroglobulinemia (WM), SHM defines a predominant mutated (MUT) subset and a minor unmutated subset indicative of naive B-cell origin. In MUT-WM, tumor cells can lack CD27 expression, raising suggestions of unusual memory B-cell origins. We recently identified such normal IgM+D+CD27-ve memory B-cells, with low levels of SHM in VH genes. While these could seed WM, the possibility remains that WM could derive from classical memory B cells that shed CD27. The utility of CD27 expression in defining memory in MUT-WM origins, then, is uncertain, but SHM unequivocally defines memory B-cell derivation in most WM. Patterns of SHM and additional IgH locus events furthermore reveal ongoing intra-tumoral diversification in WM
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Published date: March 2009
Keywords:
CD70, somatic hypermutation, v genes, waldenström
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Local EPrints ID: 73009
URI: http://eprints.soton.ac.uk/id/eprint/73009
ISSN: 1557-9190
PURE UUID: fd535aaa-5bf3-473d-9300-cc5616179c5b
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Date deposited: 02 Mar 2010
Last modified: 13 Mar 2024 21:50
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Contributors
Author:
Surinder S. Sahota
Author:
Gavin Babbage
Author:
Nicola J. Weston-Bell
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