Thrombin activatable fibrinolysis inhibitor (TAFI): a role in pre-eclampsia (review)


Dusse, Luci Maria, Cooper, Alan J. and Lwaleed, Bashir A. (2007) Thrombin activatable fibrinolysis inhibitor (TAFI): a role in pre-eclampsia (review). Clinica Chimica Acta, 378, (1-2), 1-6. (doi:10.1016/j.cca.2006.10.014).

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Description/Abstract

Pre-eclampsia (P-Ec) is a complex multisystem disorder of unknown aetiology reported to occur in about 6% to 8% of all pregnancies throughout the world. This disease is associated with fibrin deposition and occlusive lesions in placental vessels. Pro-thrombin activatable fibrinolysis inhibitor (pro-TAFI) is a relatively recently described glycoprotein that can be converted into its active form (TAFIa) by thrombin, thrombin–thrombomodulin and plasmin. TAFIa potentially inhibits fibrinolysis by removing C-terminal lysine and arginine residues from fibrin. These residues are required for adsorption of tissue-type plasminogen activator (t-PA) and plasminogen to fibrin. Therefore, TAFIa decreases plasmin formation and protects the fibrin clot against lysis. An increased of pro-TAFI/TAFIa levels has been reported in some clinical conditions associated with thrombotic tendency, as type II diabetes mellitus, deep vein thrombosis and symptomatic artery disease. Few studies have investigated pro-TAFI/TAFIa in normal or complicated pregnancy but contrasting results were reported. Understanding the role of pro-TAFI/TAFIa in the pathogenesis of P-Ec can hold great promise for improving P-Ec management. In this context, a large-scale study evaluating plasma TAFI antigen and activity, its synthesis and metabolism in pre-eclamptic women is required. Recently new selective TAFIa inhibitors have been developed. The design of a new therapy to treat and/or prevent P-Ec, based on successful use of TAFIa inhibitors, may have significant clinical ramifications

Item Type: Article
Additional Information: Invited critical review
ISSNs: 0009-8981 (print)
Related URLs:
Keywords: pro-TAFI, TAFIa, pre-eclampsia
Subjects: R Medicine > RG Gynecology and obstetrics
Divisions: University Structure - Pre August 2011 > School of Health Sciences
University Structure - Pre August 2011 > School of Medicine
ePrint ID: 73032
Date Deposited: 26 Feb 2010
Last Modified: 27 Mar 2014 18:52
URI: http://eprints.soton.ac.uk/id/eprint/73032

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