Immunotherapy for neuroblastoma: turning promise into reality.
Gray, Juliet C. and Kohler, Janice A. (2009) Immunotherapy for neuroblastoma: turning promise into reality. Pediatric Blood and Cancer, 53, (6), 931-940. (doi:10.1002/pbc.22153).
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Neuroblastoma is one of the commonest and most aggressive paediatric malignancies. The majority of children present with metastatic disease for which long-term survival remains poor despite intensive multi-modal therapies. Toxicity from current treatment regimes is already significant, and there is little room to further intensify therapy. Alternative treatment strategies are therefore needed in order to improve survival. Immunotherapy is an attractive therapeutic option for these children as it potentially offers a much more specific and less toxic treatment than conventional therapies. This review discusses the different immunotherapy strategies that may be useful in neuroblastoma, their advantages and disadvantages and the challenges that need to be overcome to successfully use them clinically.
|Digital Object Identifier (DOI):||doi:10.1002/pbc.22153|
|Keywords:||immunology, immunotherapy, neuroblastoma|
|Subjects:||R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Q Science > QR Microbiology > QR180 Immunology
R Medicine > RJ Pediatrics
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Cancer Sciences
|Date Deposited:||01 Mar 2010|
|Last Modified:||31 Mar 2016 13:05|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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