Primary central nervous system lymphoma: tumor-related clones exist in the blood and bone marrow with evidence for separate development
Primary central nervous system lymphoma: tumor-related clones exist in the blood and bone marrow with evidence for separate development
Primary central nervous system lymphoma (PCNSL) is an aggressive B-cell tumor that is defined clinically by the absence of systemic disease. We have used immunoglobulin variable (V)-gene analysis to identify tumor cells at the CNS site in 12 cases and to probe the involvement of peripheral tissues in 3 patients. Clonal tracking revealed tumor cells in the bone marrow and/or blood for 3/3 cases, with evidence for increased V-gene mutational activity at peripheral sites. In 2/3 cases, intraclonal variant analysis revealed identity with the brain biopsy, but detected additional variants unique to extracerebral sites. These findings suggest that peripheral tumor cells can undergo separate development locally with no re-entry into the brain. PCNSL appears to have both CNS-specific and systemic components with limited interchange. The more malignant behavior of tumor cells in the CNS suggests either a local environmental influence or a less malignant phenotype of the peripheral clone.
4677-4680
McCann, Katy J.
154f6b6d-c8b2-43b2-a8a9-ffe243da40c6
Ashton-Key, Margaret
5994ca63-021e-44b1-86c4-b7ae53321101
Smith, Kelly Ann
620aeeb6-7aee-401c-9f83-4a461c400f99
Stevenson, Freda K.
ba803747-c0ac-409f-a9c2-b61fde009f8c
Ottensmeier, Christian H.
42b8a398-baac-4843-a3d6-056225675797
7 May 2009
McCann, Katy J.
154f6b6d-c8b2-43b2-a8a9-ffe243da40c6
Ashton-Key, Margaret
5994ca63-021e-44b1-86c4-b7ae53321101
Smith, Kelly Ann
620aeeb6-7aee-401c-9f83-4a461c400f99
Stevenson, Freda K.
ba803747-c0ac-409f-a9c2-b61fde009f8c
Ottensmeier, Christian H.
42b8a398-baac-4843-a3d6-056225675797
McCann, Katy J., Ashton-Key, Margaret, Smith, Kelly Ann, Stevenson, Freda K. and Ottensmeier, Christian H.
(2009)
Primary central nervous system lymphoma: tumor-related clones exist in the blood and bone marrow with evidence for separate development.
Blood, 113 (19), .
(doi:10.1182/blood-2008-09-179366).
Abstract
Primary central nervous system lymphoma (PCNSL) is an aggressive B-cell tumor that is defined clinically by the absence of systemic disease. We have used immunoglobulin variable (V)-gene analysis to identify tumor cells at the CNS site in 12 cases and to probe the involvement of peripheral tissues in 3 patients. Clonal tracking revealed tumor cells in the bone marrow and/or blood for 3/3 cases, with evidence for increased V-gene mutational activity at peripheral sites. In 2/3 cases, intraclonal variant analysis revealed identity with the brain biopsy, but detected additional variants unique to extracerebral sites. These findings suggest that peripheral tumor cells can undergo separate development locally with no re-entry into the brain. PCNSL appears to have both CNS-specific and systemic components with limited interchange. The more malignant behavior of tumor cells in the CNS suggests either a local environmental influence or a less malignant phenotype of the peripheral clone.
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e-pub ahead of print date: 18 December 2008
Published date: 7 May 2009
Organisations:
Cancer Sciences
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Local EPrints ID: 73219
URI: http://eprints.soton.ac.uk/id/eprint/73219
ISSN: 0006-4971
PURE UUID: ed1ab093-e3d1-4002-a405-9b1df12fb9ba
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Date deposited: 03 Mar 2010
Last modified: 14 Mar 2024 02:40
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Author:
Katy J. McCann
Author:
Margaret Ashton-Key
Author:
Kelly Ann Smith
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