Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics
Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics
Therapeutic targeting of tumours on the basis of molecular analysis is a new paradigm for cancer treatment but has yet to fulfil expectations. For many solid tumours, targeted therapeutics, such as inhibitors of oncogenic kinase pathways, elicit predominantly disease-stabilizing, cytostatic responses, rather than tumour regression. Combining oncogenic kinase inhibitors with direct activators of the apoptosis machinery, such as the BH3 mimetic ABT-737, may unlock potent anti-tumour potential to produce durable clinical responses with less collateral damage.
321-326
Cragg, Mark S.
ec97f80e-f3c8-49b7-a960-20dff648b78c
Harris, Claire
ce357569-f567-477d-88cb-79425d886400
Strasser, Andreas
c9774edf-fa89-481c-8cc4-21f403859700
Scott, Clare L.
9aee7a06-6161-4d3b-8721-c395654dca5f
May 2009
Cragg, Mark S.
ec97f80e-f3c8-49b7-a960-20dff648b78c
Harris, Claire
ce357569-f567-477d-88cb-79425d886400
Strasser, Andreas
c9774edf-fa89-481c-8cc4-21f403859700
Scott, Clare L.
9aee7a06-6161-4d3b-8721-c395654dca5f
Cragg, Mark S., Harris, Claire, Strasser, Andreas and Scott, Clare L.
(2009)
Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics.
Nature Reviews Cancer, (9), .
(doi:10.1038/nrc2615).
Abstract
Therapeutic targeting of tumours on the basis of molecular analysis is a new paradigm for cancer treatment but has yet to fulfil expectations. For many solid tumours, targeted therapeutics, such as inhibitors of oncogenic kinase pathways, elicit predominantly disease-stabilizing, cytostatic responses, rather than tumour regression. Combining oncogenic kinase inhibitors with direct activators of the apoptosis machinery, such as the BH3 mimetic ABT-737, may unlock potent anti-tumour potential to produce durable clinical responses with less collateral damage.
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Published date: May 2009
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Local EPrints ID: 73221
URI: http://eprints.soton.ac.uk/id/eprint/73221
ISSN: 1474-175X
PURE UUID: bac418ec-774e-41af-aee9-0846ff8658e3
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Date deposited: 03 Mar 2010
Last modified: 14 Mar 2024 02:41
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Author:
Claire Harris
Author:
Andreas Strasser
Author:
Clare L. Scott
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